肿瘤为何会复发?中国科学院院士曾益新提肿瘤干细胞新"起源"说

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此为正解，然而普通的肿瘤细胞演进成肿瘤干细胞不是因为基因组不稳定，而是有更为深层次的原因。且演进的方 ...
1 |" f+ {+ A8 r- Otainlangxing 发表于 2010-1-7 09:40

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请问能不能具体举个例子  有哪些更为深层次的原因呢？ 请教请教~~

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哈哈 有意思~~ 你们之间的赌约让我想起了电影《先知》里面 的一个情节： 就是学校埋下的时间囊！~~ 要不我们搞一个类似的活动？ 就是大家想象一下10~15年之后 肿瘤研究会发展到什么样子？你觉得以后研究的主题 热点可能会是什么？

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回复 22# jiandong2001 " Y( S) n/ J+ L2 T1 M, U% K; H
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在高级模式下能够粘贴附件

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推荐大家看看这篇文章：5 b2 l2 M* x+ k. g( Q
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Cell. 2010 Jan 8;140(1):62-73.7 {7 A! O$ p0 b& ~- R* H
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Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content.
* I* g: s$ B3 Y- B) ]Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG, Di Fiore PP.$ ~% Q% n8 J  j2 h
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IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy; Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita' degli Studi di Milano, Via di Rudini' 8, 20122 Milan, Italy; Istituto Europeo di Oncologia, Via Ripamonti 435, 20141 Milan, Italy.
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Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured mammospheres, on the basis of their ability to retain the lipophilic dye PKH26 as a consequence of their quiescent nature. PKH26-positive cells possess all the characteristics of hNMSCs. The transcriptional profile of PKH26-positive cells (hNMSC signature) was able to predict biological and molecular features of breast cancers. By using markers of the hNMSC signature, we prospectively isolated SCs from the normal gland and from breast tumors. Poorly differentiated (G3) cancers displayed higher content of prospectively isolated cancer SCs (CSCs) than did well-differentiated (G1) cancers. By comparing G3 and G1 tumors in xenotransplantation experiments, we directly demonstrated that G3s are enriched in CSCs. Our data support the notion that the heterogeneous phenotypical and molecular traits of human breast cancers are a function of their CSC content. Copyright © 2010 Elsevier Inc. All rights reserved.
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PMID: 20074520 [PubMed - as supplied by publisher]+ W8 ]3 u" p9 Q- N+ ?

0 b+ H( x/ b% X7 l全文在帖子里有：http://www.stemcell8.cn/thread-16752-1-1.html

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回复  tainlangxing
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: i& g4 a, k0 x( t    也许可以“教育”肿瘤细胞，把它转成正常细胞吧，但是可行性真的是.....
( o% e: Q. k- T$ l* S1 A/ [zlightmiss 发表于 2010-2-1 13:32

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. q- u% P& A1 @9 c9 @* @8 L呵呵 其实教育肿瘤细胞变成正常细胞也不是没有过报道! M8 j- }/ n9 n

1 |7 A! T2 b& Q前几年有报道过将肿瘤细胞接种在胚胎的微环境中，可以使肿瘤细胞转化为正常细胞

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回复 89# tainlangxing
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6 u! p+ T0 F( K1 J你去这个帖子里找吧* S& T5 E; C& ?0 f' t+ h5 ]5 t
http://www.stemcell8.cn/thread-19887-1-2.html