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Mesenchymal stem cells: the fibroblasts’ new clothes?( i0 R9 w4 ]- M" P% B
ABSTRACT + y; \- I1 E, g! [
Mesenchymal stem cells are adherent stromal cells, initially isolated from the bone marrow, characterized by their ability
, H1 I: g" x* l3 v( zto differentiate into mesenchymal tissues such as bone, cartilage and fat. They have also been shown to suppress, k+ o/ _, M8 b i
immune responses in vitro. Because of these properties, mesenchymal stem cells have recently received a very high profile.# n4 t5 X, t w+ V
Despite the dramatic benefits reported in early phase clinical trials, their functions remain poorly understood.
5 B6 S' B, N5 ?+ P" r" `% UParticularly, several questions remain concerning the origin of mesenchymal stem cells and their relationship to other; t7 q2 Z0 S4 m2 l
stromal cells such as fibroblasts. Whereas clear gene expression signatures are imprinted in stromal cells of different
$ }, U' H- O9 F Danatomical origins, the anti-proliferative effects of mesenchymal stem cells and fibroblasts and their potential to differentiate
( R6 T- z6 o) u1 \* a4 f# vappear to be common features between these two cell types. In this review, we summarize recent studies in the
/ z7 x% _* `8 z/ c* G0 |context of historical and often neglected stromal cell literature, and present the evidence that mesenchymal stem cells and
. S: Z! j, q/ ]( `4 qfibroblasts share much more in common than previously recognized.
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发表于 2010-1-7 15:38
发表于 2010-11-3 10:55
