09年 Haematologic a综述 看待间充质干细胞的另一个视角

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Mesenchymal stem cells: the fibroblasts’ new clothes?
7 p+ k6 s- d& }" ?+ b0 T8 a) SABSTRACT     % u" ]* `* w3 J8 F4 G, t
Mesenchymal stem cells are adherent stromal cells, initially isolated from the bone marrow, characterized by their ability
; W8 c9 Z' v+ t" mto differentiate into mesenchymal tissues such as bone, cartilage and fat. They have also been shown to suppress
' h7 K( W/ _# R, U" jimmune responses in vitro. Because of these properties, mesenchymal stem cells have recently received a very high profile.
7 T! l" V7 g% L; uDespite the dramatic benefits reported in early phase clinical trials, their functions remain poorly understood.
# S5 Q( ^* X# o! i8 ?, F9 cParticularly, several questions remain concerning the origin of mesenchymal stem cells and their relationship to other, [4 g. T% f1 \/ P
stromal cells such as fibroblasts. Whereas clear gene expression signatures are imprinted in stromal cells of different
, D5 v) S! z8 s7 Banatomical origins, the anti-proliferative effects of mesenchymal stem cells and fibroblasts and their potential to differentiate9 r: K" G6 O9 A  j+ t7 w
appear to be common features between these two cell types. In this review, we summarize recent studies in the
$ e, E  \+ g/ b( d0 e' ycontext of historical and often neglected stromal cell literature, and present the evidence that mesenchymal stem cells and
2 {3 d$ R* B3 u2 \$ K; g! mfibroblasts share much more in common than previously recognized.
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