质疑tbx18心脏祖细胞全文

jianlindunev

Tbx18 and the fate of epicardial progenitors
( n& C  {* A( IArising from: C.-L. Cai et al. Nature 454, 104–108 (2008)
8 y0 g' P6 S3 F% ]; u( q8 Z1 uUncovering the origins of myocardial cells is important for understanding: v5 ]4 U) U0 @1 [% N" k
and treating heart diseases1,2. Cai et al.3 suggest that Tbx18-
- c/ M  F" u( p7 I" a2 _6 @' kexpressing epicardiumprovides a substantial contribution tomyocytes2 F4 o) g, S* M# H' X8 @1 A
in the ventricular septum and the atrial and ventricular walls. Here we
' k3 k2 t- T& s; c* S: C. ?show that the T-box transcription factor gene 18 (Tbx18) itself is, N8 T' ]' e$ O) h0 E5 Z2 E9 ~" B8 e
expressed in the myocardium, showing that their genetic lineage2 S9 D9 r# u' @1 }6 T- Y3 a
tracing system does not allow conclusions of an epicardial origin of2 `# `7 b1 z0 {# R; F
cardiomyocytes in vivo to be drawn.

jianlindunev