质疑tbx18心脏祖细胞全文

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Tbx18 and the fate of epicardial progenitors9 m1 E3 l. @  G) U
Arising from: C.-L. Cai et al. Nature 454, 104–108 (2008)
# }3 v; G& m( W8 }5 F. r! B5 ~Uncovering the origins of myocardial cells is important for understanding
* j/ Q, J! g# l7 x; R' fand treating heart diseases1,2. Cai et al.3 suggest that Tbx18-
+ r# |% Y- h6 D4 a5 p0 Pexpressing epicardiumprovides a substantial contribution tomyocytes7 }9 M3 {, j6 N6 i
in the ventricular septum and the atrial and ventricular walls. Here we
; o5 p5 i' N; W/ W* ]! Nshow that the T-box transcription factor gene 18 (Tbx18) itself is$ `+ t; i! e$ y+ v. K/ l4 j; j
expressed in the myocardium, showing that their genetic lineage/ l$ L( ^; d* \# @9 q; p
tracing system does not allow conclusions of an epicardial origin of
+ D& ~8 y# ?; J) |6 dcardiomyocytes in vivo to be drawn.

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