质疑tbx18心脏祖细胞全文

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Tbx18 and the fate of epicardial progenitors0 `- t- O7 H% y1 j
Arising from: C.-L. Cai et al. Nature 454, 104–108 (2008)% t  l5 I6 F0 a. e$ T' T
Uncovering the origins of myocardial cells is important for understanding
" k: x1 y; d& [. t  Eand treating heart diseases1,2. Cai et al.3 suggest that Tbx18-7 H3 \/ M7 y0 w
expressing epicardiumprovides a substantial contribution tomyocytes
* c3 q3 s, o+ ?2 ~2 I! Din the ventricular septum and the atrial and ventricular walls. Here we* K+ _% u+ }5 P5 c4 Y
show that the T-box transcription factor gene 18 (Tbx18) itself is
) y& x6 u  W' n, N' c" dexpressed in the myocardium, showing that their genetic lineage, Z5 i6 Q4 U& y9 ~% F* D8 [/ e
tracing system does not allow conclusions of an epicardial origin of$ d$ j$ H8 u+ D- ]
cardiomyocytes in vivo to be drawn.

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