质疑tbx18心脏祖细胞全文

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Tbx18 and the fate of epicardial progenitors: _/ A8 Z, v2 ]& Z% i: A! D
Arising from: C.-L. Cai et al. Nature 454, 104–108 (2008)/ M$ D, S( v5 [1 V
Uncovering the origins of myocardial cells is important for understanding
+ W! I' W: C7 o* V( J1 h- eand treating heart diseases1,2. Cai et al.3 suggest that Tbx18-6 h/ q- L, B$ B  E3 x
expressing epicardiumprovides a substantial contribution tomyocytes" W# f7 u: t( I; @& s% t7 W+ r
in the ventricular septum and the atrial and ventricular walls. Here we
1 ]8 Z) P( F" w$ @. b" Nshow that the T-box transcription factor gene 18 (Tbx18) itself is5 {/ D! C. @/ T% D, N2 ~$ q6 c7 p! }0 }, X
expressed in the myocardium, showing that their genetic lineage. A9 ~- Y  M: g" J) m
tracing system does not allow conclusions of an epicardial origin of
. \' y# Z9 W' V6 a+ ]$ K: Rcardiomyocytes in vivo to be drawn.

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