The stem-cell niche as an entity of action

ng_pan

David T. Scadden15 v* q! ^; e6 v! O* y
Stem-cell populations are established in ‘niches’ — specific anatomic locations that regulate how they
4 ?  K/ {9 D& U1 b( \7 rparticipate in tissue generation, maintenance and repair. The niche saves stem cells from depletion,
1 O. ?+ g! Q5 t' j/ R$ z7 e" c1 t1 Pwhile protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue
- ]) P. l: o" Y. t! D4 b  nphysiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms.
7 f; F3 \  Q6 i" h4 [0 o4 U5 L# IYet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The
4 V# p$ g; r) d5 pinterplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and
- e0 g2 c: q1 q) A0 u. Zfor the ultimate design of stem-cell therapeutics.
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