The stem-cell niche as an entity of action

ng_pan

David T. Scadden1: L- S- M  N- T- F( q
Stem-cell populations are established in ‘niches’ — specific anatomic locations that regulate how they0 {0 N: S5 v( ], y. u7 `
participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion,4 v6 m* I: D6 r/ Z! u3 g
while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue, U' _8 {4 s! g# |7 e1 X8 i
physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms.3 ?! p6 N" o) T6 I5 Y
Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The
! n% e- W# }! j8 g  f& O, i2 I% ginterplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and! F2 L2 R9 D7 s5 }4 q0 B
for the ultimate design of stem-cell therapeutics.! m9 r7 P/ e  ~" ~0 C- s, {$ q

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