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本帖最后由 细胞海洋 于 2015-3-12 13:19 编辑
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Embryonic Stem Cell Lines
$ q& E7 I9 v; H rDerived from Human% ^6 K8 m2 _) T6 V, j
Blastocysts1 I) Q* K7 l5 t- `# y; l+ [5 d
James A. Thomson,* Joseph Itskovitz-Eldor, Sander S. Shapiro,& I3 ]/ @$ T0 _0 P* J5 m+ d
Michelle A. Waknitz, Jennifer J. Swiergiel, Vivienne S. Marshall,
4 D. O- K* n$ ^- l$ Q& D, iJeffrey M. Jones8 T4 o0 H0 m& D$ F: V
Human blastocyst-derived, pluripotent cell lines are described that have normal
7 I7 L. U. |0 n& q$ I) `. {karyotypes, express high levels of telomerase activity, and express cell surface5 }: x* u# c: F6 o' E0 X" |
markers that characterize primate embryonic stem cells but do not characterize
) s. A! V5 R$ y0 P7 Tother early lineages. After undifferentiated proliferation in vitro for 4 to 5
6 s3 W2 q2 J) wmonths, these cells still maintained the developmental potential to form trophoblast# N9 ]+ l% ^- m' J0 F( D
and derivatives of all three embryonic germ layers, including gut r1 N1 A O, A
epithelium (endoderm); cartilage, bone, smooth muscle, and striated muscle
- p8 F) X' o0 e- |0 q(mesoderm); and neural epithelium, embryonic ganglia, and stratiÞed squamous
7 w0 s2 j+ F" h: n& wepithelium (ectoderm). These cell lines should be useful in human developmental* J3 R9 s* D% F1 A
biology, drug discovery, and transplantation medicine.
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发表于 2009-2-25 11:09
发表于 2009-6-13 12:39
