cell上最新的黑色素瘤干细胞文献

hany2007

A Temporarily Distinct Subpopulation
& X6 C& x$ g5 k6 A3 ~& q9 Fof Slow-Cycling Melanoma Cells. `. Y: d, c  s. s
Is Required for Continuous Tumor Growth
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3 J1 O/ G8 f5 e0 n. oMelanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling times of >4 weeks within the rapidly proliferating main population. Isolated JARID1B-positive melanoma cells give rise to a highly proliferative progeny. Knockdown of JARID1B leads to an initial acceleration of tumor growth followed by exhaustion" a  S9 e3 H, K4 I5 y2 ~. P' t
which suggests that the JARID1B-positive subpopulation is essential for continuous tumor growth. Expression of JARID1B is dynamically regulated and does not follow a hierarchical cancer stem cell model because JARID1B-negative cells can become positive and even single melanoma cells irrespective of selection are tumorigenic. These results suggest a new understanding of melanoma heterogeneity with tumor maintenance as a dynamic process mediated by a temporarily distinct subpopulation.% T& H8 h- o# r' X' E  V. {% J

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