cell上最新的黑色素瘤干细胞文献

hany2007

A Temporarily Distinct Subpopulation* g( |. W4 [$ [+ h! V
of Slow-Cycling Melanoma Cells; O5 o. I" L! V8 @4 G/ T  `! p
Is Required for Continuous Tumor Growth! _( X. X" U2 |( B% r/ T  z1 ^1 q8 ^  ~

, K7 v" {2 q( R' lMelanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling times of >4 weeks within the rapidly proliferating main population. Isolated JARID1B-positive melanoma cells give rise to a highly proliferative progeny. Knockdown of JARID1B leads to an initial acceleration of tumor growth followed by exhaustion. {$ C. S: d& J% m& E' p* U  a
which suggests that the JARID1B-positive subpopulation is essential for continuous tumor growth. Expression of JARID1B is dynamically regulated and does not follow a hierarchical cancer stem cell model because JARID1B-negative cells can become positive and even single melanoma cells irrespective of selection are tumorigenic. These results suggest a new understanding of melanoma heterogeneity with tumor maintenance as a dynamic process mediated by a temporarily distinct subpopulation.7 o. X8 j) R  o- z4 H

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