癌干细胞研究进展

sciential

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李锦军，顾健人*2 D: \' S4 a# Z8 I+ N9 P. Y0 W
（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）4 k' s3 u; c6 V7 _( Z' V' H7 B
摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知
& ^. R$ q4 ^4 s8 `$ }7 b; ~# @! ?识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病
' c% d/ z: A9 a) H* s机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我
% n2 g* H% E: q$ ?7 N7 T更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与
- Y; R2 H( I! B% ^8 |肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作1 [2 J; l8 A8 `$ l) F
一综述。
; b6 k/ A) M/ g! m& u9 z关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生$ |0 U, r  |; x
中图分类号：R730.21; R730.231　　文献标识码：A
, R# e, i+ y: P: J# _& S0 URecent progress in research on cancer stem cells
: p  n$ M5 F! e- |5 L6 SLI Jin-Jun, GU Jian-Ren*
' q% f# r( q1 ]4 C7 U5 x6 x(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,! f7 _/ U9 W- u3 d; x+ ]0 a
Shanghai Jiaotong University, Shanghai 200032, China)7 U2 L- r$ L. L1 X. ^3 s3 n
Abstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is5 P) R6 s, S! d
still unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of* V! g: S5 g  o
knowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily
# v& n/ `% R) ccharacterized, which might provide a novel clue for explanation of tumorigenesis and establishment of. N1 e# p- t0 @* x& r3 @6 t) U
novel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the6 y" Y: J% k* X. O
properties of self-renewal, strong potentials of proliferation, which might play important roles in progression,
* d5 C& k* g9 h0 crecurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug: ^5 V4 i$ ?. q/ W; w2 l
resistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as+ m* K4 P3 S' W
many problems that remained to be solved.
% V2 c" w; d8 U' ~. ^Key words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis
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; m  y; T; _" ^0 z; ?附件为全文，请大家支持一下 回复本贴就可以下载了2 Y% H3 x# `7 E" T) w
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horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

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1# sciential

passenger101

thanks

passenger101

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见闻

thank you!

lanbaiping

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yfancying

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