李凌松:胚胎干细胞

sciential

# s) B4 d# A  G5 S$ \& h+ A

9 f3 |, X4 W: m李凌松*，王 莉
4 ]) L; Q2 L* E（北京大学干细胞研究中心细胞生物学系，北京 100871）
8 F( O' z: K3 g+ H摘　要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学
5 Q" J) @3 P' j5 [. l特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界5 f  N5 _0 q( }/ V9 j
范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日2 g+ M* b& J% `& j* P# D, `
起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身
7 t- y+ z% Y, U6 p! V  E% P涉及的伦理学争论给予概述。! S+ X" z; |3 A& }: R
关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用
# q8 j+ b  T' }# `3 I: W# t, q, ~中图分类号：Q813　　文献标识码：A/ S* _$ \7 Y8 m. |7 L
Embryonic stem cells6 \& k  g/ r0 F5 s
LI Ling-Song*, WANG Li) `# U/ I* K. E4 P9 w+ b
(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871)5 k8 l  z7 g6 K: H# R+ j
Abstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to
1 z8 ?. n3 @7 a4 ^" atheir unique properties, ES cells are used in diverse fields of biological research，particular in developmental+ b! E: ^$ F5 j4 r; ]
biology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation  ]& a. l0 T3 {+ z0 Q" D% Q
eggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial.
& L9 k* A- L- [: z8 |' d: {This review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell: R6 G7 v) `' h& r
in treating diseases, as well as ethical issues related to human ES cells research.
, M& S! W  C& a1 f/ }9 z- i& c0 C8 EKey words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;4 y. O! q: l/ n( j" \) v
3 [; K0 k0 _/ u5 g+ z1 S
附件为全文，请大家支持一下 回复本贴就可以下载了
0 x4 d4 n- q. q
1 P, t  x! e7 P# W