李凌松:胚胎干细胞

sciential

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' L& y4 F! Z- y) i+ ^. Q/ X; ?' @李凌松*，王 莉
) ^: T9 |1 ~8 M# T（北京大学干细胞研究中心细胞生物学系，北京 100871）
8 D/ X' q: Q$ K% O& B摘　要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学
8 d7 @& A8 ^% {0 f6 `* e! d特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界
  J3 h) o% b, S范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日
8 y$ W! z; B1 q, M4 \! U起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身! w4 J! f4 |9 R. D
涉及的伦理学争论给予概述。6 E$ g' y9 J& j4 Y1 x. V
关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用
3 N! a* s! u0 X0 l! \2 h中图分类号：Q813　　文献标识码：A
# b% D, ^% ?4 wEmbryonic stem cells- x  ~/ E& `8 A. ?9 t$ g
LI Ling-Song*, WANG Li
! _4 a- i9 b+ ^$ A0 X5 ^6 S% ?(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871)  i7 F* r0 U" G* p
Abstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to8 M; q  x6 C; K4 ~2 g
their unique properties, ES cells are used in diverse fields of biological research，particular in developmental
* y9 T( P" G2 c& \' v7 K) t  ybiology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation
3 h3 m, Q9 B" X) T+ keggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial.! ~7 I: C5 k( ?) ]7 V, U  ~" m! ?* V
This review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell
5 e9 h2 n9 u7 p9 V8 R- A% `in treating diseases, as well as ethical issues related to human ES cells research.: m/ J* i! Z6 @
Key words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;" f  @: k, @% ]3 o% y3 a* L2 u

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