干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研4 v# B1 a, c. E3 P
究生院 北京市 100730- N* ]" ]; H9 |8 @$ e+ S
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学
7 `: a# S" H! w3 D科学院中国协和医科大学中日临床研究所. qianbo79@163.com
( d/ l' A8 J. Y# S! Y6 ?+ f电话: 010-84206005 传真: 010-64206643
5 g; H2 l: O7 w5 z8 D% w( Q. J( E收稿日期: 2007-03-17 接受日期: 2007-04-25
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Association of stem cells
5 \8 h4 B2 A: z$ l8 _/ J6 mand cancer stem cells with
2 U3 L4 z3 {( {2 h& btumorigenesis, @' x' i* z( w! i. x- ~
Bo Qian, Han-Qing Cai, Jie Feng
# u6 N. i/ d3 x: o- E! d1 U% @Bo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of! v/ v; }6 X" \4 m- v
Peking Union Medical College, Chinese Academy of Medical
6 B2 }7 M( A0 C2 |/ ?Sciences, Beijing 100730, China
% h2 p. m: h7 xCorrespondence to: Bo Qian, China-Japan Clinical Research
( [. V  o+ }4 u8 r8 UInstitute, Peking Union Medical College, Chinese* S. v2 v! g( Z+ Y
Academy of Medical Sciences, 2 Yinghua East Street, Beijing* Q4 c. F4 w% m$ R
100029, China. qianbo79@163.com
8 b6 B( s( X( M4 s! _8 MReceived: 2007-03-17 Accepted: 2007-04-25
; E5 \' j; Y( U+ \$ N) ^Abstract
7 w+ D( B3 U- o0 A8 ZThe research on cancer stem cells is a new hot6 r; X& a+ x4 p! N9 m1 L
spot in at present. The hypothesis indicates
! r% ^9 E; d+ c7 J) D/ Y7 }cancer stem cells, which were possibly the origin
- E7 f% H* J+ j0 Y) @/ r. Rof the cancer, come from normal stem cells. For
% m9 `/ L0 ?5 b. c7 t' etheir special characters, normal stem cells can% F: b' w* C# X& S4 e
differentiate into tumor cells more easily than/ h5 C% O! R8 x, [9 p9 ^1 _7 k
adult cells. Stem cells transform into malignant
8 H8 b9 q) j/ k0 `1 u7 G5 Z$ `cancer stem cells possibly because of gene% a/ H. X+ n  F; x( ~" F; e
mutation, abnormal asymmetry and cell fusion.7 W4 ?- N$ Z3 h3 O9 V/ f$ i
It is a main method to obtain cancer stem cells by
: W0 H4 Z$ s% l5 U& p3 @flow cytometer using different protein markers
* q& o4 o, u: K$ Q* Vand fluorescent probes. It is demonstrated that
  P! N* O5 t6 hcancer stem cells are very powerful in selfrenewal,' l9 ?  Z4 Q3 I* V7 u) s& `
proliferation, and differentiation.0 d/ R9 r% s8 }7 w
Targeting on cancer stem cells, early diagnosis* v- H5 W4 [# y; p0 c* O
for cancers might be achieved.
  w) {; {# C, T7 fKey Words: Stem cell; Cancer stem cell; Cell differentiation;% A  G1 k7 r7 V, `
Tumorigenesis; Flow cytometer, A' `' X; _9 d9 u8 u' y
Qian B, Cai HQ, Feng J. Association of stem cells and
/ q, t+ C. h; ?1 u& M& r; A; D) icancer stem cells with tumorigenesis. Shijie Huaren  ?! }& n  u: C% q+ [! W
Xiaohua Zazhi 2007;15(13):1526-1531
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摘要1 I, h9 o$ X. B6 t* B& {
肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
$ ^) f: U% Z9 a* s( z0 F* j0 J由正常干细胞恶变形成. 正常干细胞的特有性
. t7 n+ O! ^  p: `状, 使其较成体细胞更易成为肿瘤发生的靶细$ y) o- _  x6 E/ C
胞. 干细胞可能经基因突变、异常不对称分裂9 ?6 X+ E; _, |. J: ~
和细胞融合转化为肿瘤干细胞. 利用不同的蛋
6 w/ Z) e2 A  A2 \% x( B' J白标志物或荧光探针, 通过流式细胞仪分选是
# \2 _4 V& c" m" Y# H# k0 }发现肿瘤干细胞的主要方法. 已证实的肿瘤干
! d1 P+ m2 J' Z( u3 @& j/ V9 O6 |5 F细胞皆具有强大的自我更新和增殖能力, 以及
, f) |* i- W0 H5 o: d+ k  |细胞分化潜能. 针对肿瘤干细胞的检测和杀
/ v  ~3 }" u4 |伤, 可能为肿瘤早期诊断和治疗带来希望.0 Y( \7 Z" V6 \9 A4 d$ J" l/ F2 v; i
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
5 |/ ~( ^* O8 `" r流式细胞仪: u0 N7 c; X5 N& `3 X  [8 n
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jingzh1985

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sunshine520

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weiyepan

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tjutiger

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lilinfeng

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bjchen789

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