干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研
7 @0 W0 V, Q3 K究生院 北京市 100730
6 I" E# z/ G# n5 e4 G2 i通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学
: v1 O4 R/ f4 G; c" t1 P科学院中国协和医科大学中日临床研究所. qianbo79@163.com+ V6 K1 V8 ~3 _, |3 f# A2 D' _: a, V
电话: 010-84206005 传真: 010-642066431 s4 _2 M" s+ @4 U( a& [) k5 Z9 {
收稿日期: 2007-03-17 接受日期: 2007-04-25
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4 }9 V% h3 d% B; lAssociation of stem cells
7 O/ g# l0 D' {and cancer stem cells with7 B7 e9 k) b# F
tumorigenesis, }( F7 W5 ]% P. k7 q2 v8 a8 O
Bo Qian, Han-Qing Cai, Jie Feng
- i6 r* y  k7 VBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
8 c+ ^  j4 C0 P9 d- ?4 RPeking Union Medical College, Chinese Academy of Medical( |5 f3 ^0 r4 E% U
Sciences, Beijing 100730, China
8 e  [/ ^" j# X; K7 L7 E1 f3 l# nCorrespondence to: Bo Qian, China-Japan Clinical Research
" C' Q. Z' O' \Institute, Peking Union Medical College, Chinese
, {( U! \) g6 ]" Z, L; ~: QAcademy of Medical Sciences, 2 Yinghua East Street, Beijing
) S6 L( D$ g2 p# S. o' H100029, China. qianbo79@163.com
- \% W6 H. }  T0 G) W# IReceived: 2007-03-17 Accepted: 2007-04-25
; ?, [- ?# n, r/ e9 _8 n* _( ZAbstract3 g: M; R* {- y- M4 t9 x) p: j
The research on cancer stem cells is a new hot* N0 L2 k) W* b1 V
spot in at present. The hypothesis indicates( n+ \& C7 Y$ A& g
cancer stem cells, which were possibly the origin
* S9 J8 u+ f  p! |& t. jof the cancer, come from normal stem cells. For
: D2 ^* b7 G1 t% s5 Ttheir special characters, normal stem cells can
$ P( B9 k: T: i2 G+ X8 Q) P! bdifferentiate into tumor cells more easily than
9 P5 d3 ]5 u/ p% Y3 M" I$ C; Z% a0 Gadult cells. Stem cells transform into malignant
& U- s& O+ w% I4 Y8 Vcancer stem cells possibly because of gene7 N2 t: f! T/ ?/ A- Z( W
mutation, abnormal asymmetry and cell fusion.
/ ~' U* A$ v+ r' {  PIt is a main method to obtain cancer stem cells by
4 @+ ]: m7 M- ]) u  _; Yflow cytometer using different protein markers1 ^6 {6 y$ ?+ z8 b0 d
and fluorescent probes. It is demonstrated that6 ^! k! D# S" D2 Q' H
cancer stem cells are very powerful in selfrenewal,( P7 Q* d0 b4 v0 Q2 b9 W' E
proliferation, and differentiation.' Q/ V% f7 M) ^1 C# P, L5 }
Targeting on cancer stem cells, early diagnosis2 G/ f0 [( G% L. L. \3 ^& a1 X
for cancers might be achieved.
5 u: n) W" {6 L" w. ZKey Words: Stem cell; Cancer stem cell; Cell differentiation;
- U! i8 f, @8 g) BTumorigenesis; Flow cytometer( l, ^/ o) {! n0 Y) E. r
Qian B, Cai HQ, Feng J. Association of stem cells and
! l8 s* B* E6 s' r" `5 f/ p3 Tcancer stem cells with tumorigenesis. Shijie Huaren
" K, N9 h( v* K# F3 lXiaohua Zazhi 2007;15(13):1526-15313 P; G/ V6 b/ _8 T
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摘要" c6 L9 U: d$ t9 R' h
肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
) u$ {$ b, x. g% b! G, |; C由正常干细胞恶变形成. 正常干细胞的特有性. r) J3 T, h; k5 n9 L0 d* ^, z, L
状, 使其较成体细胞更易成为肿瘤发生的靶细
% ^% O4 I2 N' l* q# }胞. 干细胞可能经基因突变、异常不对称分裂* w1 C3 B8 M4 O3 ]5 t( C# N
和细胞融合转化为肿瘤干细胞. 利用不同的蛋
7 v0 `- v- A' Q4 ~白标志物或荧光探针, 通过流式细胞仪分选是% e& p3 H6 X" @! p1 v6 s
发现肿瘤干细胞的主要方法. 已证实的肿瘤干7 P9 N4 I+ Z! i6 o; Z
细胞皆具有强大的自我更新和增殖能力, 以及/ _: l' b* x. ~1 B$ t- J
细胞分化潜能. 针对肿瘤干细胞的检测和杀. l0 W8 P  }  z& \9 k
伤, 可能为肿瘤早期诊断和治疗带来希望.$ \8 h* C. A9 d* h+ n0 p/ J
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
: ?) C( v$ o2 [( f0 Z3 F8 W流式细胞仪, \# O# X& H) v( ]8 R1 @( \) ]; H

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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

ahmusht

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