干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研
6 C4 e$ m- N3 e. i3 W" P+ c究生院 北京市 100730& b& T1 |* X) D7 w! ^$ Z+ L
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学# \' Q9 j! H8 s& b1 b& t0 H0 Q% E( r9 L
科学院中国协和医科大学中日临床研究所. qianbo79@163.com# R' ^4 ?+ O5 ]
电话: 010-84206005 传真: 010-642066435 P- c; l/ v7 [) o( U: [5 l
收稿日期: 2007-03-17 接受日期: 2007-04-25) _4 z# q2 y* H! g
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Association of stem cells
+ A/ s6 l3 r# |and cancer stem cells with
5 w8 e8 K. A. u( ?* etumorigenesis& e; Y5 @2 z3 ]/ t& X5 \" T
Bo Qian, Han-Qing Cai, Jie Feng
. p# T2 T' o1 K) j' |' KBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
3 Y( V" ~$ o0 L; pPeking Union Medical College, Chinese Academy of Medical7 A9 Y4 R4 }4 X7 F3 g5 _
Sciences, Beijing 100730, China
2 E' y4 _5 w+ Z, Z* b& h) UCorrespondence to: Bo Qian, China-Japan Clinical Research# B# s: l: F2 P  a) I/ \6 g
Institute, Peking Union Medical College, Chinese5 j6 v4 a2 y5 g, |5 U- S' U
Academy of Medical Sciences, 2 Yinghua East Street, Beijing$ e; [1 U4 M9 z: }) P
100029, China. qianbo79@163.com5 m  M5 E9 L5 C
Received: 2007-03-17 Accepted: 2007-04-25( A% H/ d- M/ q1 I' m- a" U
Abstract4 ?! \8 u0 a4 \+ o* e
The research on cancer stem cells is a new hot
3 X& z% p1 h! p. W8 ]spot in at present. The hypothesis indicates" r0 ^/ E5 c8 H, Z
cancer stem cells, which were possibly the origin
$ ?  G; I( f1 d: mof the cancer, come from normal stem cells. For
5 N) n* k9 v+ U8 l1 Atheir special characters, normal stem cells can' |3 O( e( x/ A5 J! |1 ?
differentiate into tumor cells more easily than
2 z4 g, o) H! E+ E0 h, b+ r' h+ wadult cells. Stem cells transform into malignant
2 T: s4 U, Z0 z# ~, l; u9 [! I4 ]cancer stem cells possibly because of gene) m  `7 Y- h6 Q/ v2 H
mutation, abnormal asymmetry and cell fusion.4 p0 q! K9 h( D1 D/ C
It is a main method to obtain cancer stem cells by
$ Q  D( ^0 a' p4 j8 d. ]9 [flow cytometer using different protein markers
/ B6 d9 C9 v; C7 j; m+ x& x: T1 }and fluorescent probes. It is demonstrated that# [, d% F4 ^  `) I: l* S2 b" }
cancer stem cells are very powerful in selfrenewal,/ @0 f0 E0 r7 P! b  M: P
proliferation, and differentiation.
2 B( U& U, A1 N7 e1 ~) zTargeting on cancer stem cells, early diagnosis: Z+ t8 m3 N% g! C* }
for cancers might be achieved.
9 H7 N/ \4 r. R1 J" EKey Words: Stem cell; Cancer stem cell; Cell differentiation;% C; S. `" t# W, Y( d% O
Tumorigenesis; Flow cytometer
/ s$ _) ~* }6 u6 j# j; z5 Y# H! TQian B, Cai HQ, Feng J. Association of stem cells and. x' Q" g0 U( u9 {; l3 N
cancer stem cells with tumorigenesis. Shijie Huaren
1 o, t. @; t1 WXiaohua Zazhi 2007;15(13):1526-15311 U6 [0 _: _$ _7 v. X3 O- o

/ c# t& Z& |( u* v5 k+ f8 f摘要
& {$ n9 `$ V$ k" _, L" C肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
/ W+ }8 D. |& G# w5 M6 Z$ J$ V* M由正常干细胞恶变形成. 正常干细胞的特有性8 W( p6 l1 [, z9 D# d
状, 使其较成体细胞更易成为肿瘤发生的靶细9 X1 p3 M" Q9 c+ C
胞. 干细胞可能经基因突变、异常不对称分裂" H" \" K  R9 A: i
和细胞融合转化为肿瘤干细胞. 利用不同的蛋+ U2 @8 _# o: K  q2 F$ E9 f
白标志物或荧光探针, 通过流式细胞仪分选是
7 [# e8 O7 v8 W/ \& P% R2 ]- |发现肿瘤干细胞的主要方法. 已证实的肿瘤干
, A: [4 w) c5 l2 q2 ~/ r细胞皆具有强大的自我更新和增殖能力, 以及# q% m) L& s4 t5 \! T) V+ a3 H
细胞分化潜能. 针对肿瘤干细胞的检测和杀2 z: |! A* G4 k. Z) x  ?& D4 i! m
伤, 可能为肿瘤早期诊断和治疗带来希望.
" S- }( ~- N  h# K1 @: ^3 o9 j关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
5 e/ N! U  V+ I( ^2 Z流式细胞仪
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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