干细胞、肿瘤干细胞与肿瘤发生

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2 ?/ a. z% V! N3 g钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研
& {2 P: w) A. Y! B; ^究生院 北京市 100730
0 A0 a) o! B# m7 q6 R' W/ p' o5 K通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学/ R$ c/ U( f4 P- Q
科学院中国协和医科大学中日临床研究所. qianbo79@163.com& y) j! z& }2 ]
电话: 010-84206005 传真: 010-64206643* b, F: n! @& ?  O$ g+ r* }1 M
收稿日期: 2007-03-17 接受日期: 2007-04-25/ j0 m1 T8 H2 T- q' I
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Association of stem cells/ I- u7 T. `1 I+ F
and cancer stem cells with. e! R2 P, U$ R8 b; v
tumorigenesis$ d/ C( w1 k! B& y
Bo Qian, Han-Qing Cai, Jie Feng& r, r0 c6 C$ Z
Bo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
# b+ b' @( I& w$ aPeking Union Medical College, Chinese Academy of Medical* h: i3 j- S) A) A% z
Sciences, Beijing 100730, China
! k8 I7 I7 H, t/ b0 @Correspondence to: Bo Qian, China-Japan Clinical Research
1 l' d9 ]/ _" i: P& x2 M" BInstitute, Peking Union Medical College, Chinese
( \5 g2 p% `& o# z) S6 l/ mAcademy of Medical Sciences, 2 Yinghua East Street, Beijing
* q- S; P' f3 }( A* {& I% S! H100029, China. qianbo79@163.com$ f' C! V, o3 B% ^& X! T7 d) g$ N
Received: 2007-03-17 Accepted: 2007-04-25( [. P7 L/ j' Q1 l4 Y/ u
Abstract  A" m/ @) J, V, t
The research on cancer stem cells is a new hot
8 t$ a( L; a# Pspot in at present. The hypothesis indicates
* {* r7 H( U$ |% G4 v' }9 c( i! scancer stem cells, which were possibly the origin
1 m1 X+ e& V) P/ b% Fof the cancer, come from normal stem cells. For
7 ?3 E+ z; S+ v5 x% Rtheir special characters, normal stem cells can
' S, t2 H) y* K! U# \7 {differentiate into tumor cells more easily than
: ]2 l: {% k/ B0 A- _adult cells. Stem cells transform into malignant
8 _4 b( L3 u  K$ D( H3 p; Ycancer stem cells possibly because of gene
- }, ?2 g1 E; s" d$ Tmutation, abnormal asymmetry and cell fusion.
5 i* K! e" |( s" X: R( v  ~It is a main method to obtain cancer stem cells by, u" U: i# ?# h( @& W1 G
flow cytometer using different protein markers
& F: @0 V* H$ g1 yand fluorescent probes. It is demonstrated that
. `+ x5 Z# Z0 x0 w) m( ~cancer stem cells are very powerful in selfrenewal,
! G* p/ M4 M! Bproliferation, and differentiation.7 T3 T, ]0 c9 y  E; S
Targeting on cancer stem cells, early diagnosis
! G, u7 q/ Q  }, K0 r* ofor cancers might be achieved." E1 U' q2 y) [3 q3 N' d3 T# W9 P
Key Words: Stem cell; Cancer stem cell; Cell differentiation;- h8 _* r% @# L+ r; i
Tumorigenesis; Flow cytometer3 M  y6 g9 ?9 y7 H7 k' y
Qian B, Cai HQ, Feng J. Association of stem cells and! v- C. l( ]* c+ O
cancer stem cells with tumorigenesis. Shijie Huaren
# h2 |0 d  u9 B- g+ H. v$ w3 {Xiaohua Zazhi 2007;15(13):1526-1531
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; l9 h) n% z4 h$ @摘要
4 L1 k; z% ^/ D+ U8 A肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则; h3 n# e5 D0 m8 z" _: H3 M# v/ k( {1 g
由正常干细胞恶变形成. 正常干细胞的特有性
- x9 T# z/ o- p! ~# T% V- t( S状, 使其较成体细胞更易成为肿瘤发生的靶细
$ r- A5 C5 F- `) Q9 K+ }胞. 干细胞可能经基因突变、异常不对称分裂) t' k8 U' ^/ s9 Q0 K1 o2 q
和细胞融合转化为肿瘤干细胞. 利用不同的蛋6 N$ O0 }; T. h6 W# w3 r; Q
白标志物或荧光探针, 通过流式细胞仪分选是3 g1 x0 ?) E" s* d
发现肿瘤干细胞的主要方法. 已证实的肿瘤干( x- E: Y: u- R: R8 L' f! ?
细胞皆具有强大的自我更新和增殖能力, 以及
  R7 g' P  R2 q细胞分化潜能. 针对肿瘤干细胞的检测和杀
6 y; p, H  \5 c( {2 W伤, 可能为肿瘤早期诊断和治疗带来希望.
' T4 c! f- @, f1 }5 |关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;! [+ l0 o: g! f) M  A
流式细胞仪
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

ahmusht

good m

yfancying

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辛苦了

1234567

不错不错~

chenghoby

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xuyuhappyfish

感谢，感谢~~~

zhangqh

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