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Stem-cell populations are established in ‘niches’ — specific anatomic locations that regulate how they
( |! ` `# E- J) |participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion,. e# O; P! e4 D8 r; C% Y! S9 }1 q
while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue. i% o( j) t# z% I d
physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms.
% _' ^! G6 z& X' {Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The
& A$ j, }% @' g, a9 ginterplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and! B. R8 s/ ^7 f/ N
for the ultimate design of stem-cell therapeutics. |
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发表于 2010-6-19 21:04
