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Stem-cell populations are established in ‘niches’ — specific anatomic locations that regulate how they
7 E c+ k1 L2 c0 Uparticipate in tissue generation, maintenance and repair. The niche saves stem cells from depletion,3 o# s4 P4 ], |" A9 F; B- Y& A& M
while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue
1 }, }4 `) U8 c+ Y4 Y& x& |physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms.
7 F& S9 q+ r- ?$ QYet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The6 z+ Q0 N" W% t& s
interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and
$ ?* d6 i7 ~5 f2 D" ?, ?1 b F4 M0 \for the ultimate design of stem-cell therapeutics. |
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发表于 2010-6-19 21:04
