《细胞》[cell]2010年8月20出版pdf全文

scienese

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  u; @8 r8 ~: v+ D! B. h# u封面介绍On the cover: Cachexia or muscle wasting affects many cancer patients, particularly those with late-stage disease. In this issue, Zhou et al. (pp. 531–543) demonstrate that blocking the ActRIIB signaling pathway with a decoy receptor in several mouse models of cancer boosts muscle mass and prolongs survival even without slowing tumor growth. This treatment reduces the breakdown of muscle proteins by the ubiquitin-proteasome pathway and stimulates proliferation of muscle satellite (stem) cells. The painting on the cover illustrates the dramatic increase in muscle mass and improved quality of life for a tumor-bearing mouse with cachexia after treatment with the decoy receptor. Illustration by David G. Evans; Surfmedia Enterprises, LLC.0 ?" F3 R, e0 R5 U
好可爱的小鼠O(∩_∩)O哈，超喜欢~~+ `+ d6 X  m; x" w$ I

$ X( h" R, i% m/ j# l- uLeading Edge5 @; r8 d/ r" E( ]# m- ~2 {3 E
In This Issue p497
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$ C2 I- @. j3 z7 R0 S/ ?. jCell Culture p5018 G4 ~# e4 Y, _8 F6 ?2 a1 e: y
Summary | Full Text | PDF (258 kb), E0 V* A. ?6 L1 B
Essay6 b  N. j3 \9 {

6 ^$ W, u/ C9 d$ P$ K# p8 @% X# OInduced Domain Formation in Endocytic Invagination, Lipid Sorting, and Scission p507
0 O5 O/ e$ g7 i) @5 FLudger Johannes, Satyajit Mayor) ~1 `% R/ S8 g4 U3 _
Summary | Full Text | PDF (450 kb)8 a( _+ f4 D4 {; A- O7 P
Previews7 h9 s( t3 l9 `- |3 {6 ^( T

  T+ K6 B* o+ D  S2 y" aReversing Cachexia p511
  P; _' Z6 Y3 iMichael J. Tisdale4 s1 l! z8 U% ^/ R- c1 i5 Q
Summary | Full Text | PDF (345 kb), ~5 C6 ~5 R) G+ E" `" f. n! t
The Ins and Outs of EGFR Asymmetry p513
% Y0 A  f8 @& i4 T9 ]Daniel J. Leahy6 J* \9 N1 I3 Q, m
Summary | Full Text | PDF (324 kb)
2 M: I2 I+ K) N) r  g3 pUp a Hydrophobic Creek with a Short Paddle p5158 R5 V0 Y: |/ ^: y0 V1 ^
Raymond E. Hulse, Qufei Li, Eduardo Perozo
# ?, P+ }, N9 d/ k& g* H4 ^Summary | Full Text | PDF (218 kb)
; E" O9 E7 ]9 r/ j3 tThe Immunoproteasome Cleans up after Inflammation p517
3 s% r3 @8 ?' ?! C. KSjoerd van Deventer, Jacques Neefjes
( e/ g2 e6 P4 eSummary | Full Text | PDF (205 kb)
7 T- `" n& U( V: OReview
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Featured Article
7 S% y7 g4 w# f- A6 e1 o0 Y8 {2 q' ^2 BCellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective p5192 x* }" J* c5 i! R
Daniel A. Koster, Aurélien Crut, Stewart Shuman, Mary-Ann Bjornsti, Nynke H. Dekker( N* f( P4 L5 m5 ^9 t
Summary | Full Text | PDF (1484 kb) | Supplemental Data( C' v& t2 t8 |' W4 z
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Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival p531
. T/ l" I9 k" ^, [Xiaolan Zhou, Jin Lin Wang, John Lu, Yanping Song, Keith S. Kwak, Qingsheng Jiao, Robert Rosenfeld, Qing Chen, Thomas Boone, W. Scott Simonet, David L. Lacey, Alfred L. Goldberg, H.Q. Han! N  j  X# Y9 a. p8 m  u
Summary | Full Text7 @- M; u0 Q8 T
PcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps p544! E, }+ U2 m7 M$ G8 }+ n! {
Jeehae Park, Sua Myong, Anita Niedziela-Majka, Kyung Suk Lee, Jin Yu, Timothy M. Lohman, Taekjip Ha
2 V) `  {1 f' x" mSummary | Full Text  M" P$ b7 A* |
The Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments p556# X4 K9 S$ @! U* G
Kevin D. Corbett, Calvin K. Yip, Ly-Sha Ee, Thomas Walz, Angelika Amon, Stephen C. Harrison6 l: j+ e2 n- C5 v% f' o+ v, R
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% j/ x+ a0 Z9 z. o8 W6 rStructural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor p568
% I% b" R6 Z$ I" C; {: ~5 ~, C3 }Diego Alvarado, Daryl E. Klein, Mark A. Lemmon3 U$ L3 S& i' H: i" e, l4 C( K
Summary | Full Text
. d/ [% T' y( i0 ~A Shaker K+ Channel with a Miniature Engineered Voltage Sensor p580+ W; w5 M/ ]2 c1 X" C
Yanping Xu, Yajamana Ramu, Zhe Lu
5 J) z) q# B7 K/ \6 T, I+ YSummary | Full Text7 V4 w6 o! e" I
ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death p5909 r( I% x, _4 l+ B' h
Lilliana Radoshevich, Lyndsay Murrow, Nan Chen, Estefania Fernandez, Srirupa Roy, Christopher Fung, Jayanta Debnath, W+ |4 A% J+ U, I3 u8 k
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& d3 o! i  o. XIdentification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity p601# _: S! ?5 t. v+ @2 e3 g, f
Tjakko J. van Ham, Mats A. Holmberg, Annemieke T. van der Goot, Eva Teuling, Moises Garcia-Arencibia, Hyun-eui Kim, Deguo Du, Karen L. Thijssen, Marit Wiersma, Rogier Burggraaff, Petra van Bergeijk, Jeroen van Rheenen, G. Jerre van Veluw, Robert M.W. Hofstra, David C. Rubinsztein, Ellen A.A. Nollen4 y& P  ]& U' g
Summary | Full Text
# n/ j$ [" y$ z- ^6 r, E2 }Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress p613
% D; _7 g  D6 u0 p9 H- VUlrike Seifert, Lukasz P. Bialy, Frédéric Ebstein, Dawadschargal Bech-Otschir, Antje Voigt, Friederike Schröter, Timour Prozorovski, Nicole Lange, Janos Steffen, Melanie Rieger, Ulrike Kuckelkorn, Orhan Aktas, Peter-M. Kloetzel, Elke Krüger
  q9 M* Y# Q8 @3 E& d) g7 \0 ySummary | Full Text* x/ N* K) X  ~& Z) A2 [
An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis p625
! \0 ^( ?1 s# ]! r# \; ^  s3 gMichael J. Moore, Qingqing Wang, Caleb J. Kennedy, Pamela A. Silver
7 K; @0 T* g% t+ a1 xSummary | Full Text
7 T( F; ]6 |# g; I/ L6 E! G0 m% Z  mResource# H% Q4 B- R% w6 G9 e2 s% _; T2 H
Featured Article
% N: o9 N. S- X0 G4 F5 mActivation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease p637
, D( @: G# c9 b: M1 s) k$ w' hDaniel C. Gray, Sami Mahrus, James A. Wells
2 \% }# k. p/ ~5 A7 D$ ?Summary | Full Text1 _1 u5 Y* I* t( K$ t
SnapShot- _* q# u1 [  d2 o+ B* h# v+ ]8 F
SnapShot: Homologous Recombination in DNA Double-Strand Break Repair p648.e1
( ~" O# C* D( m7 O  i: ?Gerard Mazón, Eleni P. Mimitou, Lorraine S. Symington
2 B5 z- R5 ^1 p2 e4 lPDF (1491 kb)" e5 p2 B$ b8 E" L
想看赶紧下哦，呵呵
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1 I5 g6 p0 V& d. C2 R# U[hide][/hide]

加菲猫

表观遗传学

HongHong

说的真有道理啊！

狂奔的蜗牛

我等你哟!  

张佳

发贴看看自己积分  

lalala

任何的限制，都是从自己的内心开始的。  

干细胞2014

感谢党和人民的关爱~~~  

再来一天

一楼的位置好啊..  

红旗

你加油吧  

蝶澈

老大,我好崇拜你哟