《细胞》[cell]2010年8月20出版pdf全文

scienese

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3 @6 l( X1 e$ R封面介绍On the cover: Cachexia or muscle wasting affects many cancer patients, particularly those with late-stage disease. In this issue, Zhou et al. (pp. 531–543) demonstrate that blocking the ActRIIB signaling pathway with a decoy receptor in several mouse models of cancer boosts muscle mass and prolongs survival even without slowing tumor growth. This treatment reduces the breakdown of muscle proteins by the ubiquitin-proteasome pathway and stimulates proliferation of muscle satellite (stem) cells. The painting on the cover illustrates the dramatic increase in muscle mass and improved quality of life for a tumor-bearing mouse with cachexia after treatment with the decoy receptor. Illustration by David G. Evans; Surfmedia Enterprises, LLC.
! K2 S6 B2 A7 |- s 好可爱的小鼠O(∩_∩)O哈，超喜欢~~
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Leading Edge% c! _+ w, L, C2 ?# d  j* r# z# ?
In This Issue p497
* E! G/ I: l% d% i( [+ ~! W7 f/ WFull Text | PDF (273 kb)
$ K& N0 E; u0 |# cCell Culture p501
# ?7 j9 e! C8 y" P) X0 ySummary | Full Text | PDF (258 kb)
5 D+ a+ n6 a0 L! {; C9 d1 [1 _Essay, L/ S7 x! ^% q$ w2 {: L! G3 C

) g1 M$ {, l$ r. I' P4 K8 a( U2 C. DInduced Domain Formation in Endocytic Invagination, Lipid Sorting, and Scission p5074 K5 f9 l2 {  y2 c2 B) V
Ludger Johannes, Satyajit Mayor' @+ x. p$ ~4 U6 k$ q+ D5 r) [
Summary | Full Text | PDF (450 kb): Y6 F; p+ a+ @* c- T% v, L
Previews
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" {- R5 u. p# x5 }Reversing Cachexia p5118 h/ a/ Y3 [& i( `% D! j- T9 y) t
Michael J. Tisdale
2 C% `4 w  Z0 a. N: ^% E/ iSummary | Full Text | PDF (345 kb)) v$ p0 W% ]1 l( b) R
The Ins and Outs of EGFR Asymmetry p513
; M5 H  ]( X2 V6 L# M3 aDaniel J. Leahy; }& D" y! x; W' L+ e- a
Summary | Full Text | PDF (324 kb)
; s/ }: h8 w( F7 e4 r5 TUp a Hydrophobic Creek with a Short Paddle p515
: r( g* B; h9 a1 O9 M4 {* QRaymond E. Hulse, Qufei Li, Eduardo Perozo
  ~, p# Z' @/ k" o8 {" F6 VSummary | Full Text | PDF (218 kb)1 D+ O& }/ _! L2 d
The Immunoproteasome Cleans up after Inflammation p517
( F/ c- X4 c( _4 ]9 M! z. T, cSjoerd van Deventer, Jacques Neefjes
# s" f# D  S: z3 \# o: BSummary | Full Text | PDF (205 kb)5 s6 R5 |) ]# x  ?+ j3 j8 E5 t
Review
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Featured Article" i4 k9 }& C4 u: N
Cellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective p519) t. l* \7 v6 o, w3 m/ y
Daniel A. Koster, Aurélien Crut, Stewart Shuman, Mary-Ann Bjornsti, Nynke H. Dekker- v- Q) ?; Y" w' ]4 q" D9 C1 W
Summary | Full Text | PDF (1484 kb) | Supplemental Data4 `% ]( ^% m$ M, Z4 c, e
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Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival p531
; P: [6 R+ ]/ A& @& EXiaolan Zhou, Jin Lin Wang, John Lu, Yanping Song, Keith S. Kwak, Qingsheng Jiao, Robert Rosenfeld, Qing Chen, Thomas Boone, W. Scott Simonet, David L. Lacey, Alfred L. Goldberg, H.Q. Han
9 _- b" x! u8 V" hSummary | Full Text
, k5 T2 v( _. s# b1 cPcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps p544* w+ T9 n: W  D8 ]7 r- Q
Jeehae Park, Sua Myong, Anita Niedziela-Majka, Kyung Suk Lee, Jin Yu, Timothy M. Lohman, Taekjip Ha$ n% x- R& }) D# o  N: T8 H
Summary | Full Text
& }8 C3 `6 X" ^The Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments p556
; \5 g& _* H8 n. N+ PKevin D. Corbett, Calvin K. Yip, Ly-Sha Ee, Thomas Walz, Angelika Amon, Stephen C. Harrison, w  O) ?# J& X% a- F* N
Summary | Full Text6 ?3 A% `9 o" K9 D# C6 y
Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor p568
) L3 I4 y  T2 m1 hDiego Alvarado, Daryl E. Klein, Mark A. Lemmon
0 C, S& F! y/ C0 ASummary | Full Text
% ~3 @$ l6 K! U, j( N- M  KA Shaker K+ Channel with a Miniature Engineered Voltage Sensor p580
: i, f. V& _: G0 }$ x. U  wYanping Xu, Yajamana Ramu, Zhe Lu3 s9 N3 B* v; }8 x5 F+ N8 H+ e* ]
Summary | Full Text9 [' l/ j2 E9 C- M- g% m6 ~( ]
ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death p590: X. A$ h3 F6 ]$ H/ H. [8 ]
Lilliana Radoshevich, Lyndsay Murrow, Nan Chen, Estefania Fernandez, Srirupa Roy, Christopher Fung, Jayanta Debnath
% S1 B+ z9 o3 [  |Summary | Full Text% O% k1 h. U& y9 F/ ?
Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity p601
6 a  N6 Z& `+ G$ X$ H: F! B9 sTjakko J. van Ham, Mats A. Holmberg, Annemieke T. van der Goot, Eva Teuling, Moises Garcia-Arencibia, Hyun-eui Kim, Deguo Du, Karen L. Thijssen, Marit Wiersma, Rogier Burggraaff, Petra van Bergeijk, Jeroen van Rheenen, G. Jerre van Veluw, Robert M.W. Hofstra, David C. Rubinsztein, Ellen A.A. Nollen
6 p. R% u7 i2 C' ~1 ASummary | Full Text
  v# |+ p/ Q7 V* N6 xImmunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress p613( ~" t* |$ U8 G7 c
Ulrike Seifert, Lukasz P. Bialy, Frédéric Ebstein, Dawadschargal Bech-Otschir, Antje Voigt, Friederike Schröter, Timour Prozorovski, Nicole Lange, Janos Steffen, Melanie Rieger, Ulrike Kuckelkorn, Orhan Aktas, Peter-M. Kloetzel, Elke Krüger1 B$ S3 q! B, g% k/ d! p$ Q" Q! E/ C; p
Summary | Full Text
+ o4 r- B2 b: L: {- J7 VAn Alternative Splicing Network Links Cell-Cycle Control to Apoptosis p625
3 {- a. W/ P2 n0 n) L0 G4 O+ b# RMichael J. Moore, Qingqing Wang, Caleb J. Kennedy, Pamela A. Silver
! C. b# m, T6 ]& aSummary | Full Text
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Featured Article
( j  @  L: ?5 W( _Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease p637( {; Y& k! m; Y) F
Daniel C. Gray, Sami Mahrus, James A. Wells9 `& A$ P7 O- E4 u, H: X
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SnapShot
* @0 t- ]7 z; z) ZSnapShot: Homologous Recombination in DNA Double-Strand Break Repair p648.e1
$ \, K; j6 r8 `  S5 x. H$ d/ sGerard Mazón, Eleni P. Mimitou, Lorraine S. Symington
( J0 k" C) S4 B) P: r( |PDF (1491 kb)# Y' i9 i# }  a2 \+ s
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