《细胞》[cell]2010年8月20出版pdf全文

scienese

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  Z  G1 d% G' c4 h- w! q封面介绍On the cover: Cachexia or muscle wasting affects many cancer patients, particularly those with late-stage disease. In this issue, Zhou et al. (pp. 531–543) demonstrate that blocking the ActRIIB signaling pathway with a decoy receptor in several mouse models of cancer boosts muscle mass and prolongs survival even without slowing tumor growth. This treatment reduces the breakdown of muscle proteins by the ubiquitin-proteasome pathway and stimulates proliferation of muscle satellite (stem) cells. The painting on the cover illustrates the dramatic increase in muscle mass and improved quality of life for a tumor-bearing mouse with cachexia after treatment with the decoy receptor. Illustration by David G. Evans; Surfmedia Enterprises, LLC.
$ e: }0 B; b/ n( W$ t- d8 K4 U9 s 好可爱的小鼠O(∩_∩)O哈，超喜欢~~
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Leading Edge
) U/ ?  S" ]7 ~: n3 R  d* cIn This Issue p497
  j) v& A$ x4 zFull Text | PDF (273 kb)
7 R4 }" a% O; F6 L  ICell Culture p5018 [2 W/ J2 l' o/ s2 l
Summary | Full Text | PDF (258 kb)
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! f& Q4 e! G; j3 P6 X& R1 V# sInduced Domain Formation in Endocytic Invagination, Lipid Sorting, and Scission p507
1 F% l' q& W* J9 J- K3 }' O1 V7 G6 DLudger Johannes, Satyajit Mayor
2 v3 H3 B( F" V9 d$ x" D, c0 wSummary | Full Text | PDF (450 kb)3 r+ Q, J: A( Q0 K
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Reversing Cachexia p5114 c" ^/ x# p+ p
Michael J. Tisdale
4 O- [$ _9 `% T. f- qSummary | Full Text | PDF (345 kb)& t7 \& L' x+ W# o; _( G
The Ins and Outs of EGFR Asymmetry p513
/ h+ N/ H/ F) q/ O/ A- {Daniel J. Leahy0 x4 I2 o" {! O' w) H3 s5 l
Summary | Full Text | PDF (324 kb)+ [2 v: m3 ~; h1 y# G
Up a Hydrophobic Creek with a Short Paddle p5155 n$ _1 @* G4 m! \
Raymond E. Hulse, Qufei Li, Eduardo Perozo
! n' {, {+ a6 U4 aSummary | Full Text | PDF (218 kb)
0 ?- ~% C. ]3 sThe Immunoproteasome Cleans up after Inflammation p517
5 G. X( k4 v5 a4 qSjoerd van Deventer, Jacques Neefjes# q- |( o5 f" }, y% R; C& {
Summary | Full Text | PDF (205 kb)
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5 v" K, u& p+ W4 {9 O4 O- ?3 lFeatured Article
7 T& W, ?  L+ W# YCellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective p519$ N3 j% R. b- ]6 \( S8 k
Daniel A. Koster, Aurélien Crut, Stewart Shuman, Mary-Ann Bjornsti, Nynke H. Dekker
( ~$ J- d5 m. k0 `% t# pSummary | Full Text | PDF (1484 kb) | Supplemental Data) R- s& F3 ?. g' e3 `- k/ I: f) h3 N
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Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival p531) T$ d+ K3 _9 h9 P- E
Xiaolan Zhou, Jin Lin Wang, John Lu, Yanping Song, Keith S. Kwak, Qingsheng Jiao, Robert Rosenfeld, Qing Chen, Thomas Boone, W. Scott Simonet, David L. Lacey, Alfred L. Goldberg, H.Q. Han
, a4 I9 t4 W# Z% g; E% GSummary | Full Text
1 d% _$ b' _+ S; ]PcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps p544- Z- S2 |2 C( f& D2 |0 D8 t& k5 @
Jeehae Park, Sua Myong, Anita Niedziela-Majka, Kyung Suk Lee, Jin Yu, Timothy M. Lohman, Taekjip Ha
& G. L) W" G* H: bSummary | Full Text
7 N( C' h- K$ e/ F/ }9 _, g) XThe Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments p5569 _) m! L$ B. n; r
Kevin D. Corbett, Calvin K. Yip, Ly-Sha Ee, Thomas Walz, Angelika Amon, Stephen C. Harrison
# R: Z0 F! U" _9 w, ?7 uSummary | Full Text
' x6 I) `+ h4 K4 j9 {6 T9 D9 oStructural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor p568# w: R5 _: n# u
Diego Alvarado, Daryl E. Klein, Mark A. Lemmon8 M2 z8 |4 m3 P* F! D; J7 F
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A Shaker K+ Channel with a Miniature Engineered Voltage Sensor p580- R' n. G# B7 h- f5 o
Yanping Xu, Yajamana Ramu, Zhe Lu& u! K2 ^" v( [+ z- V
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# Z* c" a$ N2 `2 Y3 B; pATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death p590
& Z1 X% r1 H- ^& E2 XLilliana Radoshevich, Lyndsay Murrow, Nan Chen, Estefania Fernandez, Srirupa Roy, Christopher Fung, Jayanta Debnath
6 u1 q5 V  L/ v' F) n, t0 ^Summary | Full Text$ n9 G7 i7 h- P# z1 P& C. s
Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity p601, Q6 m) u3 E& @& M# u& H
Tjakko J. van Ham, Mats A. Holmberg, Annemieke T. van der Goot, Eva Teuling, Moises Garcia-Arencibia, Hyun-eui Kim, Deguo Du, Karen L. Thijssen, Marit Wiersma, Rogier Burggraaff, Petra van Bergeijk, Jeroen van Rheenen, G. Jerre van Veluw, Robert M.W. Hofstra, David C. Rubinsztein, Ellen A.A. Nollen  O1 J* u5 ^0 _4 r9 \, d5 m
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: N  M$ M. O) p: W% P) q# ^Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress p613
! H; s7 F5 ~2 C; ^3 d8 z  d1 ]Ulrike Seifert, Lukasz P. Bialy, Frédéric Ebstein, Dawadschargal Bech-Otschir, Antje Voigt, Friederike Schröter, Timour Prozorovski, Nicole Lange, Janos Steffen, Melanie Rieger, Ulrike Kuckelkorn, Orhan Aktas, Peter-M. Kloetzel, Elke Krüger+ a' C" D9 I& W. ?% b9 [
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An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis p625
/ H  A" G' u. mMichael J. Moore, Qingqing Wang, Caleb J. Kennedy, Pamela A. Silver& `5 R3 O; f8 o' _7 n- U) w/ [7 Q
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0 u% `/ V- H. _/ _* W* AFeatured Article
: j+ ^: R, F3 n+ p. DActivation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease p6379 H9 X, c9 G# J  u
Daniel C. Gray, Sami Mahrus, James A. Wells: ~2 p7 b6 x4 h8 P3 m3 o" p; d
Summary | Full Text
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5 t+ V( F8 ]: fSnapShot: Homologous Recombination in DNA Double-Strand Break Repair p648.e1
7 o5 }1 R. |0 ^! M& ]& g1 iGerard Mazón, Eleni P. Mimitou, Lorraine S. Symington
. N. M2 W& Q8 P7 ]: TPDF (1491 kb)% N3 a' K2 G. @0 `) E
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张也行

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mckf111

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initiation

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懵懂干细胞

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susannajoke

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