《细胞》[cell]2010年8月20出版pdf全文

scienese

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- `' N8 u& A' s4 q& [6 U. D封面介绍On the cover: Cachexia or muscle wasting affects many cancer patients, particularly those with late-stage disease. In this issue, Zhou et al. (pp. 531–543) demonstrate that blocking the ActRIIB signaling pathway with a decoy receptor in several mouse models of cancer boosts muscle mass and prolongs survival even without slowing tumor growth. This treatment reduces the breakdown of muscle proteins by the ubiquitin-proteasome pathway and stimulates proliferation of muscle satellite (stem) cells. The painting on the cover illustrates the dramatic increase in muscle mass and improved quality of life for a tumor-bearing mouse with cachexia after treatment with the decoy receptor. Illustration by David G. Evans; Surfmedia Enterprises, LLC., `$ E+ W& G2 H9 D/ t
好可爱的小鼠O(∩_∩)O哈，超喜欢~~* D- Y8 A1 [8 l) q: S7 Y

, D$ L  V9 Y$ SLeading Edge
* x5 n9 \) Z2 S, Y  vIn This Issue p497
1 s$ e1 ?2 E1 P5 |: o2 ?% V$ NFull Text | PDF (273 kb)! _1 I/ }' K5 }3 d" U7 |$ p" o& [# v3 w
Cell Culture p501: T  Z, m  ^( s% b3 f* k
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Essay
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Induced Domain Formation in Endocytic Invagination, Lipid Sorting, and Scission p5070 R2 ?* c: [$ t
Ludger Johannes, Satyajit Mayor+ U5 D; R3 r8 d2 [
Summary | Full Text | PDF (450 kb)
. g6 |: [9 J* e, I2 ]9 jPreviews6 b5 h, [; s; h4 L

4 V# S( F, S$ O, HReversing Cachexia p511
1 |. c+ \2 ~% B1 ?0 w5 N, mMichael J. Tisdale: I  T0 o; C7 ]/ i( ^# m) r8 K# Z
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The Ins and Outs of EGFR Asymmetry p513
1 Z' ^. R, h: iDaniel J. Leahy: ?; p1 Q/ Z% N+ l4 p9 f
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Up a Hydrophobic Creek with a Short Paddle p515* d3 N$ q& S) a
Raymond E. Hulse, Qufei Li, Eduardo Perozo3 }+ t* P  V. i  A9 I+ h) f" |
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4 Q. B% _  c  T+ BThe Immunoproteasome Cleans up after Inflammation p517& D% V+ g: Y9 \1 {
Sjoerd van Deventer, Jacques Neefjes5 ]3 ~  O! B6 j3 A9 G7 v; r
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Review
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Featured Article8 F* l  _1 D3 U) E( {4 M* @) b5 n* J
Cellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective p519, P, \; t2 V* m; Y5 ?  S  W
Daniel A. Koster, Aurélien Crut, Stewart Shuman, Mary-Ann Bjornsti, Nynke H. Dekker
5 X( I: z5 s: W" X" E* D1 z" `6 Y1 |9 ASummary | Full Text | PDF (1484 kb) | Supplemental Data
7 W) a  i* r! K/ E8 bArticles
! E8 [8 v0 ^+ R( _! O& z, ?Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival p5317 P" I2 Z  X) e& a
Xiaolan Zhou, Jin Lin Wang, John Lu, Yanping Song, Keith S. Kwak, Qingsheng Jiao, Robert Rosenfeld, Qing Chen, Thomas Boone, W. Scott Simonet, David L. Lacey, Alfred L. Goldberg, H.Q. Han+ d" X3 T- P! K, ~% X2 O4 w) u# [
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PcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps p544
( r* S0 u6 M4 z& a- lJeehae Park, Sua Myong, Anita Niedziela-Majka, Kyung Suk Lee, Jin Yu, Timothy M. Lohman, Taekjip Ha
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! Q( ]# Z/ t3 \8 i* e; s) eThe Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments p5568 W1 Q# Q$ \( H
Kevin D. Corbett, Calvin K. Yip, Ly-Sha Ee, Thomas Walz, Angelika Amon, Stephen C. Harrison3 W0 ~- W) m% Z3 m" z: b/ m
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Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor p568: ~  k0 d- i2 S* ?- U
Diego Alvarado, Daryl E. Klein, Mark A. Lemmon
, S9 d5 G! r* S$ Y- NSummary | Full Text3 T0 B+ S4 S, y
A Shaker K+ Channel with a Miniature Engineered Voltage Sensor p580
8 H: r( c5 B" f/ S6 q) w! ~: IYanping Xu, Yajamana Ramu, Zhe Lu3 q8 g  y& b1 d  ?7 o- S
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ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death p590
& m, g) C# @9 R( GLilliana Radoshevich, Lyndsay Murrow, Nan Chen, Estefania Fernandez, Srirupa Roy, Christopher Fung, Jayanta Debnath
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Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity p601
$ d7 ]' |. o8 [- g! n, y! r1 X2 ?4 ?# HTjakko J. van Ham, Mats A. Holmberg, Annemieke T. van der Goot, Eva Teuling, Moises Garcia-Arencibia, Hyun-eui Kim, Deguo Du, Karen L. Thijssen, Marit Wiersma, Rogier Burggraaff, Petra van Bergeijk, Jeroen van Rheenen, G. Jerre van Veluw, Robert M.W. Hofstra, David C. Rubinsztein, Ellen A.A. Nollen
+ }- q9 n! ^( F; q2 g, i: XSummary | Full Text
7 L8 ?) {5 u& V7 o' AImmunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress p613
0 Q: r$ \3 R6 y) I; @# U: d$ X# @Ulrike Seifert, Lukasz P. Bialy, Frédéric Ebstein, Dawadschargal Bech-Otschir, Antje Voigt, Friederike Schröter, Timour Prozorovski, Nicole Lange, Janos Steffen, Melanie Rieger, Ulrike Kuckelkorn, Orhan Aktas, Peter-M. Kloetzel, Elke Krüger8 R$ J0 ]! T* @
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  @/ f0 Y  t, J7 i- WAn Alternative Splicing Network Links Cell-Cycle Control to Apoptosis p625. @8 k- S  W. {
Michael J. Moore, Qingqing Wang, Caleb J. Kennedy, Pamela A. Silver
" s' r' q% K* Q, k* U5 m( bSummary | Full Text5 d% k" ^6 R: g$ I, C8 X
Resource
; |0 X  b% Q2 U$ ~0 }Featured Article
$ V! |- U* v! C% C9 rActivation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease p637
0 r5 C+ K% {9 |5 R; {/ P0 [Daniel C. Gray, Sami Mahrus, James A. Wells0 H/ e! r; \* ^5 }
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SnapShot
7 ~9 U4 O' h2 ?" z+ W0 ]1 b+ b* qSnapShot: Homologous Recombination in DNA Double-Strand Break Repair p648.e1
- J8 M/ e6 n# P% S! n3 S, S! aGerard Mazón, Eleni P. Mimitou, Lorraine S. Symington+ D/ a1 e" c- U8 M8 @5 k
PDF (1491 kb)
% ^& v# x, t( H想看赶紧下哦，呵呵
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张也行

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baixueyao029

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军医

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aehxing

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mckf111

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initiation

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懵懂干细胞

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豆腐干

好好学习，天天向上

susannajoke

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