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本帖最后由 细胞海洋 于 2010-8-20 19:47 编辑 . X1 z2 ?4 f" Q4 {* {5 y
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封面介绍On the cover: Cachexia or muscle wasting affects many cancer patients, particularly those with late-stage disease. In this issue, Zhou et al. (pp. 531–543) demonstrate that blocking the ActRIIB signaling pathway with a decoy receptor in several mouse models of cancer boosts muscle mass and prolongs survival even without slowing tumor growth. This treatment reduces the breakdown of muscle proteins by the ubiquitin-proteasome pathway and stimulates proliferation of muscle satellite (stem) cells. The painting on the cover illustrates the dramatic increase in muscle mass and improved quality of life for a tumor-bearing mouse with cachexia after treatment with the decoy receptor. Illustration by David G. Evans; Surfmedia Enterprises, LLC.
' S$ f# Q& j6 A' X 好可爱的小鼠O(∩_∩)O哈，超喜欢~~ O- O* p. j' E* E+ b
* X9 Y- X, l* eLeading Edge
1 v: f' j4 H. D" M# \1 w. gIn This Issue p497
1 a: Q1 s4 n) I$ PFull Text | PDF (273 kb)
; W3 u- N. B- N5 C' S: zCell Culture p501
* H/ d1 k2 d, H" QSummary | Full Text | PDF (258 kb)
/ `! L8 W. q; r; N: w9 ^4 ~3 QEssay9 g6 e+ J2 Y/ k: D) T# F l; X
' y2 k+ |4 e4 l& `Induced Domain Formation in Endocytic Invagination, Lipid Sorting, and Scission p507+ c: c4 ]% ^4 @ |1 s- {) d8 p" ]
Ludger Johannes, Satyajit Mayor1 c$ A3 w3 Z: e* E& W- V+ q8 O: t
Summary | Full Text | PDF (450 kb)! L3 H6 v' ` t8 g1 Y" j6 q6 \
Previews
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/ P7 _! W' f" i6 n+ jReversing Cachexia p511
6 q) O/ l, f( S8 x$ v1 iMichael J. Tisdale
2 i1 v7 k7 k" b d& T* DSummary | Full Text | PDF (345 kb)
' [- P" K; D0 OThe Ins and Outs of EGFR Asymmetry p513
Q2 y; a; l0 i$ DDaniel J. Leahy
% e, w: \& X% ESummary | Full Text | PDF (324 kb)+ d2 s5 Q3 B5 k, ^
Up a Hydrophobic Creek with a Short Paddle p5159 M8 V! ~( ^# y1 x" R9 m
Raymond E. Hulse, Qufei Li, Eduardo Perozo
* o. s- ~7 K8 s9 d1 y9 G7 p0 P7 o7 b, J7 `Summary | Full Text | PDF (218 kb)$ F( i) {0 R" P# O' D
The Immunoproteasome Cleans up after Inflammation p517# @# K4 _8 Z# M+ w( ~
Sjoerd van Deventer, Jacques Neefjes
0 p7 ?8 k' [- F q: _Summary | Full Text | PDF (205 kb)/ y$ H3 [9 p+ s+ T2 R# w% J! _
Review# E- `# h3 n, Q$ Q0 B ~3 U* x
* I% n; ] \& m DFeatured Article
% X% f3 t$ g) ~% ?0 SCellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective p519
: ]- A/ L2 n( A/ M6 y: i& ADaniel A. Koster, Aurélien Crut, Stewart Shuman, Mary-Ann Bjornsti, Nynke H. Dekker
" B0 n% Z4 Y e$ }/ V& nSummary | Full Text | PDF (1484 kb) | Supplemental Data
- j. U* V+ e; S0 R! r4 x- sArticles! Y% r9 q6 U' E7 _; c
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival p5310 Y6 |8 l { F4 r h8 {
Xiaolan Zhou, Jin Lin Wang, John Lu, Yanping Song, Keith S. Kwak, Qingsheng Jiao, Robert Rosenfeld, Qing Chen, Thomas Boone, W. Scott Simonet, David L. Lacey, Alfred L. Goldberg, H.Q. Han
% l, E* Y. K7 lSummary | Full Text$ W6 [* m; l$ \0 y# P3 o. J
PcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps p5444 {( b6 H; t+ W0 D/ s( @. ^
Jeehae Park, Sua Myong, Anita Niedziela-Majka, Kyung Suk Lee, Jin Yu, Timothy M. Lohman, Taekjip Ha
: h$ ~5 S( x0 X& s2 v8 OSummary | Full Text
6 V$ Q7 X) A5 R+ uThe Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments p556
; p: v( C$ u5 D8 C }7 bKevin D. Corbett, Calvin K. Yip, Ly-Sha Ee, Thomas Walz, Angelika Amon, Stephen C. Harrison
' H- {" _, f% M: R" ^1 |Summary | Full Text" `9 w- u$ A* H8 ~: P. |
Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor p5688 u1 p+ v) D+ q# Y- B/ e$ p t5 N
Diego Alvarado, Daryl E. Klein, Mark A. Lemmon
- a' q+ V. R" e' tSummary | Full Text
6 Q1 k a3 ]8 a: n. cA Shaker K+ Channel with a Miniature Engineered Voltage Sensor p5801 ~* J$ W+ u- |/ z$ T
Yanping Xu, Yajamana Ramu, Zhe Lu
6 F# l; ^% J# E1 C4 J/ |% CSummary | Full Text. H1 ^. i1 K/ R# G
ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death p590
: ` h, H8 G$ [% OLilliana Radoshevich, Lyndsay Murrow, Nan Chen, Estefania Fernandez, Srirupa Roy, Christopher Fung, Jayanta Debnath
4 u: _1 x5 I3 U8 ESummary | Full Text `7 v5 G+ _2 i1 O
Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity p601
4 n4 L- J; ?1 ^ v. ^4 [Tjakko J. van Ham, Mats A. Holmberg, Annemieke T. van der Goot, Eva Teuling, Moises Garcia-Arencibia, Hyun-eui Kim, Deguo Du, Karen L. Thijssen, Marit Wiersma, Rogier Burggraaff, Petra van Bergeijk, Jeroen van Rheenen, G. Jerre van Veluw, Robert M.W. Hofstra, David C. Rubinsztein, Ellen A.A. Nollen
/ Q, `* d1 V1 M' ^8 h2 N# ?7 T9 y2 RSummary | Full Text* ]6 _) i& B" ^! [7 G0 l
Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress p6134 \7 ~- R6 V; Y( c3 a, \# F
Ulrike Seifert, Lukasz P. Bialy, Frédéric Ebstein, Dawadschargal Bech-Otschir, Antje Voigt, Friederike Schröter, Timour Prozorovski, Nicole Lange, Janos Steffen, Melanie Rieger, Ulrike Kuckelkorn, Orhan Aktas, Peter-M. Kloetzel, Elke Krüger' T2 a2 v {& V/ W# C1 P
Summary | Full Text
6 A% W' d' V9 S4 I" pAn Alternative Splicing Network Links Cell-Cycle Control to Apoptosis p6252 U. K4 ~; i$ c2 z* A' s
Michael J. Moore, Qingqing Wang, Caleb J. Kennedy, Pamela A. Silver
Y5 w( Z1 f1 X/ |" s% x5 YSummary | Full Text
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Featured Article
3 t' Z) @3 j6 _Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease p637
4 e+ |% s3 u j! D& Q; B( }Daniel C. Gray, Sami Mahrus, James A. Wells5 o7 x! b8 W; ^
Summary | Full Text
) O7 l4 F8 G% K7 |% wSnapShot# `. u# e8 Y; A
SnapShot: Homologous Recombination in DNA Double-Strand Break Repair p648.e1
/ \+ f) F% G: A4 F, X' x UGerard Mazón, Eleni P. Mimitou, Lorraine S. Symington
' K4 X, `4 S' @+ cPDF (1491 kb)
% Q: ]! Q) ~+ ], F/ m b5 L想看赶紧下哦，呵呵) K N9 `2 s1 I( ]) {
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发表于 2010-8-20 12:27
