求助一篇文献

woosheng

http://www.nature.com/gt/journal ... abs/gt2010130a.html
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+ I, v( }. T# m  a) Y) BGene Therapy advance online publication 30 September 2010;
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Progress and prospects: stem cells and neurological diseases
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3 _8 S) k6 S2 T: d- n" oS Gögel1, M Gubernator1 and S L Minger
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2 L: l. G+ R% q3 A5 IAbstract：
+ p3 F5 @, O9 A  YThe central nervous system has limited capacity of regenerating lost tissue in slowly progressive, degenerative neurological conditions such as Parkinson's disease (PD), Alzheimer's disease or Huntington's disease (HD), or in acute injuries resulting in rapid cell loss for example, in cerebrovascular damage (for example, stroke) or spinal cord injury. Although the adult brain contains small numbers of stem cells in restricted areas, they do not contribute significantly to functional recovery. Transplantation of stem cells or stem cell-derived progenitors has long been seen as a therapeutic solution to repair the damaged brain. With the advent of the induced pluripotent stem cells technique a new and potentially better source for transplantable cells may be available in future. This review aims to highlight current strategies to replace lost cellular populations in neurodegenerative diseases with the focus on HD and PD and traumatic brain injuries such as stroke, discussing many of the technical and biological issues associated with central nervous system cell transplantation

fire1001

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OK

woosheng

非常感谢