利用ipsc进行肝细胞分化的研究多吗？现在进展如何？

ninakwung

如题，想了解目前ips分化方面的进展，特别是肝细胞分化方面的进展。目前这方面的研究多吗？有很多利用不同来源的体细胞进行诱导的文章，但是ips定向分化的文章貌似不多。肝细胞定向分化的更是不多的样子。请高手指教。。

linlicau

回复 5# linlicau

linlicau

回复 4# linlicau
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再添两篇文章：分别报道了从iPSCs诱导分化为功能性肝细胞！4 c! ^- K8 E3 D# f0 n
Generation of Functional Human Hepatic Endoderm from Human Induced Pluripotent Stem Cells
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Highly Efficient Generation of Human Hepatocyte–Like Cells from Induced Pluripotent Stem Cells
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5 \2 u9 I8 M! `' L还有两篇文章，分别是国内邓宏魁的一篇还有国外的一篇, w) S% {) c2 ~" t
没下来，给出网址，欢迎交流。1 F$ n; U0 F# Q+ X7 w) x$ ^
http://www.nature.com/cr/journal/v19/n11/full/cr2009107a.html
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linlicau

回复 3# ninakwung % y; E1 ~/ Q, c1 d: S8 k$ d
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外加一篇文章，也是今年的，
: R/ n$ \7 U* c7 X$ Q) t" |Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells2 J) z* ]8 [. Z, L; N
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报道了产生hiPSC和分化成功能性类干细胞的文章。# X) \% |# F. {( o: T

/ c/ R- N5 B8 T& p" h; g1 q9 Y' Y原文：

ninakwung

回复 2# linlicau
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    非常感谢~~

linlicau

回复 1# ninakwung ; q) u5 [. [$ V9 N$ z7 W
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题目：Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells! n* p+ A  O) Y  r1 Z0 f
发表在著名杂志JCI（Journal of Clinical Investigation，IF=15.387）上，最新文章！6 P; K& r/ a, q. P1 W
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本文章1.不仅从α1-antitrypsin deficiency,familial hypercholesterolemia, and glycogen storage disease type 1a这三种肝病的病人诱导出iPS；2.还有效分化：Each line was differentiated into hepatocytes using what we believe to be a novel 3-step differentiation protocol in chemically defined conditions；3.且最后模拟并重现了疾病情况：recapitulate key pathological features of the diseases affecting the patients from which they were derived, such as aggregation of misfolded α1-antitrypsin in the endoplasmic reticulum, deficient LDL receptor–mediated cholesterol& {: x8 A3 U% v' {$ o8 O  P* y# i
uptake, and elevated lipid and glycogen accumulation.( E# `4 T& `9 G3 H' X
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原文：5 y6 Z4 C1 t' N7 O( N* x& E