iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：
, m) s0 v: ~. J: g0 e/ j1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).5 L" y2 Y. B" A' ]
神经疾病：
) f/ h- K. s2 W0 R$ ]$ `' p% \2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).0 b8 c  `, p. ]- L
神经疾病：9 X5 t' t% O  f$ d* N+ z9 J* d
3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
$ T! [7 Z  `  s5 c神经疾病：
7 e( U1 j6 H0 F4 y. e; O/ V4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
8 K" F, @0 {, ~$ m; ^5 h) q2 y糖尿病：
. a8 j4 F) a9 U9 X! p- w9 C5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).$ i5 K! w2 i. f' o! h( c
血液疾病：$ c' {! f( y+ i
6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.
$ H' Z4 A% C# ^; Lgenomic imprinting disorder：' M, u! X3 Y- q+ {* W

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# E2 p7 R) x* y& F. T% K9 D成功观察到疾病细胞表型的：9 H& ?1 D$ A" ?# B! n% m. W" E* N
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
0 V  l' V2 N4 A# P7 r' @+ G神经疾病：
! y$ k; }( @' v3 o8 B7 ]" ~8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).
7 ], X+ @. P/ P( e神经疾病：$ D  c3 h. E* E6 V$ R! `
9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).; Q! ]4 |0 a, z' X5 p: ]
血液疾病：$ I" s8 D; Y) E2 [& ]& m  i
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).8 i* P8 x4 R" ]  I( U
肝脏疾病：3 i2 X! S) f6 G" d/ N# \
11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).5 f1 o4 {- h  t
心脏疾病：
9 t8 B3 M( w7 m6 _12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).1 _8 n& c9 M8 `/ w& _
肝脏疾病：
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau   [, K3 o. M$ g; }4 E: V2 S7 ]6 {3 s

% ?5 |  h' F8 q! e外加一篇：3 i/ h% j. X- @& v+ T
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome# g& h4 T# Y1 g1 U4 C1 y2 a
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau / N& X3 M- `% o- ~9 z1 }

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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
3 c$ S9 P0 i  m' P% q6 UFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
9 |) d+ D2 B! B6 _原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们