iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：
) M# n1 f* Z' }% [, A; C/ {1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
- a* K& w; Q6 X; S神经疾病：
( y- `+ P; r  E  _, h2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).) p; T; R# ~" v6 j& c4 {
神经疾病：8 M; a3 o/ N" o) h5 q8 U
3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).1 K+ X  T9 l: B: s5 L; R+ ]3 \( H
神经疾病：; F+ o9 Q1 ]: t9 L9 N& p3 o9 u' J
4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).) x6 u" N/ |/ x- d7 }2 o4 s$ j' S
糖尿病：3 k# v7 f: s" J6 {9 Y9 |" ?2 f
5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009)./ ^  P8 v) C( N7 M
血液疾病：8 K$ H: P  j  w2 P! f, u- d
6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.
9 _' r$ N! B2 x, }genomic imprinting disorder：0 m! u# \4 h. h$ d! M4 ~, @1 d: O

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成功观察到疾病细胞表型的：
! t* D3 M$ I9 F# T$ ^/ J7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
0 Q7 t* ^  G5 r5 x神经疾病：
3 Y. m3 \( X6 W8 Y8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).5 i8 C: ~; q  s2 A
神经疾病：
& Z' P; x) R' \! [1 W9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).6 B: c; u! F. \4 [4 D4 K
血液疾病：
. G; A+ C$ L8 o2 G  O9 p10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).# u! Z* I* A+ |1 X# i, e5 S
肝脏疾病：
' ]% Z7 ?1 n, I; v+ }/ s11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
( c* }5 X( a1 d# V3 \/ O, Y心脏疾病：
* S. ]- l* K# P0 z+ Z2 G12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
' M$ }" N6 M( S$ @+ S肝脏疾病：3 a) }$ M0 b: `* {' g' j
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau 8 E+ O- q% @( S* _5 p. @

+ O+ t; K* ^( p  r外加一篇：+ y& Z3 t: }) U8 S
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
% B2 E4 Y! l; v2 k! JLEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau
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  c1 I* c" }) N$ Z0 W* y# y14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
3 I- e3 L6 d& v: a2 Z4 XFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
8 q; ^3 l! Q  V4 A' M+ M) E( ~+ g原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们