iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：5 z6 u4 a9 W% R
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
/ I- {- ~# I- C% v) m5 v- g$ q1 ]神经疾病：) l/ ^* i  Z  R- _
2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).  z: i9 J$ _+ M5 v; B
神经疾病：
& B& ?) |" Y; ~3 P+ q' P$ B2 ~3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).6 K8 Q( d  v" T. S* `5 m  w
神经疾病：
; _! ?) U7 ^* o2 W5 @" d  x4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).6 v+ b+ Q- I6 R& l% }
糖尿病：
. q. k' ?$ R& Q! H& S4 R5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
1 O0 _+ o; P2 p0 L血液疾病：
% X; L( e) z" I. s6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.
8 ]2 H- x% l' @( Q* Ggenomic imprinting disorder：
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) C9 n6 f" T% [; |: D* `成功观察到疾病细胞表型的：, |, Q6 H  O: q& }& ^
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).+ i) H% Q! H6 T) [$ b/ ]
神经疾病：6 m& u0 k6 b; {$ L* D6 F
8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).  R8 \9 Q1 ~! r) J6 U+ @) Z5 ]0 l9 X
神经疾病：
" B1 \) }" q3 i4 o+ m9 K+ G9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
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$ f! m: G9 Y1 j, d# Z5 t10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010)., u* }: R  b1 z' A, x/ ~: b/ o: O
肝脏疾病：
# g, m; B1 g0 X, M0 [11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
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12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
) D  y9 A  n6 r/ @: S肝脏疾病：
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% i8 M0 _- o  W: \, x( K" t$ b望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau 2 T4 v( I+ f  U9 [% t' F
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外加一篇：. y% _6 \/ G" O( {4 }/ Q. S) h& u
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
* B" v1 l4 E0 H) PLEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau : P7 a. M( T& h) V5 T  i

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* P- _- |: j7 w( B; Z% Z4 N14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability2 v5 k" m! o0 B% x7 J
Friedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。& Z. S  X" y. y, J1 U7 O0 H! A
原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们