iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：' Y! h4 b+ Z% ^+ a* K. H. Y# v# T
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).0 H! [6 M" M$ a7 G
神经疾病：
$ o$ t0 t: x& c/ p! Q# O: d2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
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3 Q# J- N; C9 U! K& Q# q6 W' A8 l3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
6 e' a6 I7 F2 P9 j/ V3 J神经疾病：
0 s; m* y* _% M; M4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).) O7 \1 N9 F  f$ f( c. G& M$ S( p
糖尿病：# ^$ C* h% _8 ]  l; E0 B
5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).# j; x8 r5 Y  q1 K/ E. U, ~
血液疾病：
* @$ t' G! ]- _; U! s) F6 Y' S6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.0 o2 v" J) H( j7 z" h5 z
genomic imprinting disorder：
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) ?$ I+ o) ^9 J% z% P1 u& H' A' k成功观察到疾病细胞表型的：
2 H: M1 r3 J8 X1 U7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
1 ?; v6 ?; Z+ x4 r! @6 \神经疾病：
8 i. z7 t. i$ ?9 u6 w  [3 f8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).
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9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
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  Y: G! ]. k6 z4 B& k3 m9 n10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).8 D2 r; {, X! J) @7 P, u
肝脏疾病：5 D5 K; P+ ]6 T0 A" m
11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).7 z: Q: Z& \" F/ r0 n  e
心脏疾病：- J0 U- t( |& x+ ~
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
: ~1 |- S! p7 Z# h7 L肝脏疾病：+ O. ]1 m( o6 S6 k' A
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
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外加一篇：$ \# t, U% Y" K9 Z8 e7 W7 f9 A# Q
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
! }$ f& z; \  N3 aLEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau 7 G' v% o% }+ @
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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
- h1 `/ v" ^6 p! j% T2 x- L# BFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。  w7 ?( V, h& A
原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们