iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：# c% K# B2 r0 F7 x" Y
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
2 l9 T' q( M$ R. c- h神经疾病：: [: @0 ~. \% \
2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
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3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
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1 ~5 B1 B0 P. R. U: @! z: s4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
1 g  _( C4 H! E; R; x2 U糖尿病：
2 F6 m# G' ]- ?& z; Z; O# O5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
6 ~# \7 |! H5 s$ w1 m5 C1 w( z; f. J" T血液疾病：
+ x9 l7 ]& I! `0 q0 e6 x  n% V6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.* b' ~' ]" C6 E, N
genomic imprinting disorder：6 L) O9 ]' J4 n- u8 U
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8 d' E, M! P! J' f- Q+ G  Z成功观察到疾病细胞表型的：7 ^/ W  P! z1 J4 c- r* n
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
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9 C' t1 M# k3 p- ~% k. z9 r8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).8 @5 c* t7 I: }! i! y2 `5 {
神经疾病：
9 U. a( g5 f1 H, b- M& `9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
+ R/ S4 b# k2 P% A0 H! g8 S3 O5 l" D  Q血液疾病：4 J8 M& e7 K/ Q4 a: C6 p
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).6 G5 E6 R) G- y9 z$ t% E( R, v- Z7 q' }3 G
肝脏疾病：. R; }0 ~( A: Y/ ]
11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
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12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).9 I0 X6 w( @) g* d
肝脏疾病：
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) ^& ]8 w7 R6 j1 N1 m望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
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, B: Z4 Q: O. F$ k4 X0 X- w1 m; F外加一篇：: I/ J+ ~. B3 x5 I- |  {
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
& z- h8 \8 E: r# ?LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau
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0 O* ~2 X" X" E' f1 \14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability+ D$ R8 Y8 H( G$ g; s+ g
Friedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
" O1 c2 ^, C8 s. B原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们