iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：
5 u; L8 ?7 F. C% ~: d1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).6 a2 w6 C) T& j5 ^( u; B" L
神经疾病：
5 j" a' D0 @& h1 K6 m9 n2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
9 ~: }  s. x$ D8 t5 W# H神经疾病：% d' V# G& N1 l
3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).2 Y0 n" _8 e# X
神经疾病：
4 y6 M0 p" {$ I+ u' N! U; r4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
5 l3 ^, S; W% I8 f4 N糖尿病：
1 _# \5 ^* W- ^3 F+ _" R5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
* Q  V  Q# T9 {" M9 H2 A血液疾病：
' Y5 @% j6 m1 c: H8 W+ B6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.
! v- O  z7 d1 J: Z  Sgenomic imprinting disorder：& O! C% N; ]$ p" ?; _

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) l' R+ t, ?5 u- M! E. ^成功观察到疾病细胞表型的：; R6 k- Q: [* w. o4 G' G
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
" v8 ^* x! N; U5 x5 x$ D神经疾病：
# B0 N5 F8 P; F% Q8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).
* L& H+ L% m5 a" K6 Z$ G6 X/ e1 D4 h神经疾病：. w( p1 c& e4 {6 D- u5 s
9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).- L: [) X3 }% ~3 s
血液疾病：0 y# [# Z. q7 S9 S: z  `5 {
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).# T; W; R6 H0 P2 j2 d, V, P( T. v, [4 R
肝脏疾病：
4 j8 x1 `7 z9 d' F, |11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).2 Y. z& S. |/ D" y# w6 D
心脏疾病：' X( a, a8 P5 J' s; h' S
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).' ~7 b4 A& Z) L: J
肝脏疾病：
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
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* W! b/ V. j" K. ?- \- `8 |外加一篇：
5 {* O# s& f* ]/ f' ?1 z6 m13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome* ]$ B) f0 E& g- z- R0 u8 E  k
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau $ ~2 O( ?0 h' C8 {8 j

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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
# P- X" X0 D4 @. B& ?: j" V8 I/ u1 V3 b/ bFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。% @4 @: H5 _$ M. q. r' u$ D
原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们