iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：
) h8 Q' e& c7 g2 c1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).5 P1 i4 w# C. Q3 |, V0 M# c. X
神经疾病：
/ m3 [; |' A) D* H/ i  N2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
3 a% }5 Q. K+ r: L6 A) |神经疾病：$ Q+ F- i. ]$ G7 }. n# C
3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).* d  L' b% E1 i2 y  ?
神经疾病：0 a8 t& K' J$ j# y% T! Z. Y
4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
2 B& ~) C1 ~2 ]5 ^" Z糖尿病：+ n# o# r* K3 n3 o
5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).! y; t8 r& ?; R; l4 L! ~
血液疾病：
+ f( |% }, Z, R# R) y* t6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.* A& g# }( X6 T: i- J
genomic imprinting disorder：, z; a/ W1 ~9 x# ]* u: l& `

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# s0 ]% |% V! H成功观察到疾病细胞表型的：0 V8 U. w; d0 W2 }
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).0 X% b' g6 \& c7 e+ {3 Q6 E
神经疾病：
, B0 [5 O- a3 X1 l2 a9 @- |) C8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).. g$ u6 d8 Z9 ^
神经疾病：2 |" ]" T7 F+ _/ G4 d, [
9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).$ Q- ]) A* ?# L& m  B% u4 K" }
血液疾病：6 T3 p# C5 v/ i7 S
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).) H6 x* b$ _- b2 P3 \" N2 N
肝脏疾病：
% H. p' }+ C5 K  W1 s8 v, o$ `11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).+ I7 c' i. A# v3 x! U
心脏疾病：1 ]. f) ?5 v$ L5 j' K
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).7 X  E3 a8 n3 @, s9 w
肝脏疾病：- V6 c# m4 x/ |
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
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" q* H) ]+ ~# t6 U+ z' \8 u, d7 d( p外加一篇：6 r4 ^8 m' h/ j. F7 T
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome% D- H; I7 y* ^: C
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau
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* {5 b9 ^5 z: ?' ^& f14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
5 {1 X7 b2 D  j" P% e1 MFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。4 V/ }' z% y  b; ?. G, C
原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们