iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：7 Q7 c4 Z, N/ ]  E' U/ k
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
7 j# s. X" c& O0 o! O神经疾病：/ g5 Z/ t8 y! a5 c
2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).. k4 {6 j9 q! G/ ~6 Y
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3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
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4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).- A0 ], g5 j, @5 C
糖尿病：4 M. S3 w$ f- @/ J" }* ?
5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
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6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.. M( r# {) o, a' ^
genomic imprinting disorder：) V. m9 i) p5 q, ?* c. I  `* v' e
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4 y3 ^$ b# P7 S- [, c成功观察到疾病细胞表型的：
/ l3 G+ a. }; ?3 n7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).8 X* a# y3 [$ @9 m- z2 ?
神经疾病：
" Q3 B- M8 M3 I& `4 k8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).
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$ g( F( I& B+ s2 U$ c' @3 ]9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
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10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).; }$ O+ [' [) j6 m% E# s
肝脏疾病：
6 B9 o* J4 ^' Z8 J4 S' i4 N11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
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& w, M/ X: s/ H( ^* @, H% D) c12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
: ]1 C$ e) |* z# ~; k) h0 |肝脏疾病：; z4 F4 B. N3 \9 j$ h" C; ^
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau 5 N; |4 @  l3 X! R" n# a5 u

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13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome6 {! O* [7 i. H, R# h$ l
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau
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. q0 a0 f/ {9 @14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
( h& a8 ~, T/ f7 q! i/ q: O0 |Friedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
  k% {$ m- v& Y原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们