iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：
; f2 g+ p8 D: U* D2 K7 R1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
: F8 V5 S. G# u7 Z神经疾病：7 j  H% l. ?$ a
2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
: L0 f' z# a  A3 j6 ]8 i) O神经疾病：) B7 ]( P2 A% r. n$ {# X
3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009)./ C7 _% P+ O. I. a6 p2 U& P
神经疾病：* H% j) e2 j/ L9 [; U3 M6 e
4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
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5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
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5 p3 U3 C- _8 a( ?' k6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry./ W+ \; g/ T7 }" W# ?
genomic imprinting disorder：: A0 W, |& ^- h2 |/ N0 O4 V: @. m
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成功观察到疾病细胞表型的：
8 C7 Y, B0 y; r- H7 b7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
$ U. X1 |# m5 X$ a# t神经疾病：
; J4 h: @+ k% s5 U$ E8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).' d. Z& ]: Y7 `
神经疾病：
: X$ K. s) p$ j0 j. d, u9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).7 {: l/ g( Z! w  e
血液疾病：
# T( h% r% w2 ^( E10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).0 z9 y4 z7 r2 g6 \7 ~1 Y/ t
肝脏疾病：1 Z6 J" R" ?( @! R2 ~; c% Y
11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).& D6 {: s3 \5 ?, T6 d; q' R- m
心脏疾病：! c5 r8 ]! i/ L( ?  j; ^
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
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. r% ]" W( R- X  P9 c0 @望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau 7 x* o3 \& F3 u5 C# ^* K
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外加一篇：) Z" r/ d% L( k6 V+ u; l0 j
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome1 l# @( G  h; y
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau 2 Z0 K) J+ H  M8 R% `

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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability" `' t  N' X. \
Friedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。: L" k- [: r& T+ j0 E7 V, ~+ Y
原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们