iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：
* o0 a8 \2 Z( w" J* ?7 J3 y0 X& G1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
3 l% f4 B, i  |: i# h神经疾病：
, a* I) Q$ X$ j' h. X2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
7 ^! _! ~  O* y( _8 r神经疾病：
# A6 F' b6 Y: ~, z+ J: |3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
$ a" ~% S! {& H$ ?神经疾病：
3 p- i& D* ^' e9 ~' k6 C4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).. f1 ^( m1 l  \; X& n
糖尿病：
; F9 [3 `8 M6 R9 E  l, X( |+ {& ]5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
% E( b3 z- A+ N* `# `血液疾病：- y6 n- g* g: E6 ?, j$ Q4 l
6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.4 C  z' e" @( F" S6 A; ^7 G' ?% s# |
genomic imprinting disorder：
: _) B( U1 t6 @$ Z9 r4 B9 h, I$ E$ W* O. F, |! J& L
4 H$ M$ t3 Q! y8 V
成功观察到疾病细胞表型的：
: R) l; |; |, v7 _7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
! {- @8 C  x" U/ w+ K( E1 K神经疾病：" Z$ F2 `8 v9 Q. K; M0 p1 v
8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).- |+ x% m" h: m$ o
神经疾病：0 q* @% |  L- o: v" h3 P' W- H  z# i
9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
( f/ x, o8 E9 i$ p血液疾病：3 e' |+ s5 _  w2 b, b, T# K1 J- Z
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
9 E# M* g5 ]7 Y% P9 \. Z/ `0 I肝脏疾病：4 X' _) z! U7 z3 a1 z* f' \# K4 m7 i7 R" @
11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).% ~, [1 G8 O% N" D
心脏疾病：2 d/ ^: I$ N9 q* K% S( `
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
' h. v9 \/ z5 k肝脏疾病：
" L( a/ E3 v0 l9 E$ n- }2 E4 E; `& n# l; T( {: y
望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
6 `7 ]' e- M3 P0 B9 C' h0 F+ ~0 A7 ?( K3 Q
外加一篇：  B9 v% D& `+ l
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
: Z4 K) V8 f! q/ b$ E0 PLEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau * v! b( C# W0 P0 f

* A! K! _+ q& ~  S* {) I* S/ @- i$ M) Q  z4 M( m; m% n/ F% a5 {" z6 a
14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability3 {% m0 w; a$ v' S; \  V( ]
Friedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。% M+ u) [* v& {6 ^
原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们