iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：( v( R% R) Y+ M, B4 |: F
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).# i# c3 d0 }& s/ \2 j9 ]
神经疾病：
$ o4 u6 G1 U9 l0 S0 e( v2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
/ u( E# C; e" @' y$ ?神经疾病：
/ i7 p# t" W) ~( p5 K5 ^( K3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).2 B$ x7 v; c& z& V5 F8 ?) H
神经疾病：4 C% J' N( S' f; N! ?
4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009)." q& a. Y7 P7 I- {; ]
糖尿病：
/ N4 ]* Y; Q1 m/ c, a& q2 U7 ~/ J5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
- ~1 G: _- }- ^; P血液疾病：
5 t/ _: q( h$ |6 d9 B6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry., ^' N) v7 ?7 d* [: L2 G& U
genomic imprinting disorder：
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成功观察到疾病细胞表型的：
9 o  s9 r* {, O+ |+ k- b7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).$ u& n! |0 t( z
神经疾病：
& m7 M: y7 b* y4 h8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).1 U8 S: I. _) \$ \1 C
神经疾病：5 V6 M9 U3 r8 C3 W1 j
9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).# ?( B: [- ?9 w* J
血液疾病：* e8 S  K" s+ }# `& e8 R3 D
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
8 D' A3 L# a1 q& [# `4 l肝脏疾病：) W* Y: m5 o- \) g
11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).( l! W  t+ w8 g
心脏疾病：
8 y2 O* e+ T( u3 s12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).( w4 P9 t  t. L/ m
肝脏疾病：! u& o$ J9 Z4 N1 O! M% j# B" j. u
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau * P% |1 M/ S( X2 `) E- V

2 Z1 G9 M; |. x7 l; q: Q2 s外加一篇：
. G5 S2 i7 ^# g" d13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome6 `& R4 l- I# A: f7 I! X( v, @4 h. K
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau
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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability! H0 q7 I3 F" _: |7 c8 W( l" t
Friedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
4 y+ ^3 Z8 e' O: S7 A$ ]0 i% \" Z原文：