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1 Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010). / w4 v3 `' O# o* J* s1 }% d
2 Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
6 D7 P9 T2 a6 H) P/ @3 Sullivan, G.J. et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 51, 329-335 (2010).4 S% [' h. W* _4 B& f* s9 p
4 Si-Tayeb, K. et al. Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells. Hepatology 51, 297-305 (2010).
3 m; z$ E3 P5 N" N) _9 Q5 Song, Z. et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res 19, 1233-1242 (2009).2 V5 b- _. a o7 b0 F5 ?
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神经细胞7 Y( X* H5 {- J1 d5 w1 N
neural crest precusors' z. J- {6 t2 K+ `& D
6 Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009). 4 t' D: O& i3 {
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neuroepithelial cell1 R5 a" G. D8 j& C% [9 `, Z
7 Hu, B.-Y. et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of the National Academy of Sciences 107, 4335-4340 (2010)
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motor neurons【包括文献7】 v) n# I# C8 _$ u" Q; J4 R- b) \
8 Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).$ M) R1 @% \& { ]
9 Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009). ; X/ ^" u( c/ V; d2 E9 k8 g
10 Chambers, S.M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotech 27, 275-280 (2009).
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' @7 C9 |$ C6 Q& P4 [0 \9 Bdopaminergic neurons of the midbrain 【包括文献10】
j5 H: {* m3 R11 Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
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; i6 s5 K0 ]3 \: F; g) Y( C y1 Eglia 【包括文献7,8】5 j0 N! `, X7 X
, r5 D2 o7 Q# ]/ F& X0 W8 C* t视网膜细胞: s4 B" C* _- P' P2 P" b/ A f' p
Retinal Pigmented Epithelium
/ K4 s+ P0 u0 c6 ]7 l12 Buchholz, D.E. et al. Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells. Stem Cells 27, 2427-2434 (2009).
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# p7 j8 \) m. i1 Z2 _; b: Tretinal cells
" w3 j! j* K+ Z" _$ \13 Osakada, F. et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci 122, 3169-3179 (2009).0 r5 K. r2 q& I( \' d
14 Meyer, J.S. et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proceedings of the National Academy of Sciences 106, 16698-16703 (2009).7 L1 z, C/ x; X+ q V9 x9 L
1 N8 A$ l1 P# j3 U7 p! x心肌细胞 cardiomyocytes1 a- q/ ?9 O8 p* v. F
15 Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).: w" w( c, q+ b- _
16 Carvajal-Vergara, X. et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465, 808-812 (2010).# G- r' h0 P) Z+ s
17 Zhang, J. et al. Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells. Circ Res 104, e30-41 (2009).2 H" I# |# f8 m- {$ I) L" K: ^
18 Zwi, L. et al. Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells. Circulation 120, 1513-1523 (2009)., J* g& u$ ^( R
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haematopoietic progenitors
j3 p1 x) n0 b+ K19 Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).) m4 ]3 x* E; K% [) D
20 Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
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blood cells
+ D' P: e$ p. p6 x1 t" [21 Choi, K.-D. et al. Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells 27, 559-567 (2009).8 x. d" P% [- @$ X `" v
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vascular endothelial cells【包括文献21】
' B* V# P- ?' h' ]- Z# s7 r22 Feng, Q. et al. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence. Stem Cells 28, 704-712 (2010).
: C+ L! p" F; }3 ~. C3 g$ K1 l23 Taura, D. et al. Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells--Brief Report. Arterioscler Thromb Vasc Biol 29, 1100-1103 (2009).
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胰岛素产生细胞 insulin-producing cells
- D0 K. L5 L+ k, M3 w; ~* a24 Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
# X/ y* c* L/ S* {25 Zhang, D. et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 19, 429-438 (2009).8 v& h, V0 P- e( M0 a' ~
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原生殖细胞 primordial germ cells$ b7 ] H p/ ]7 C, z; Q8 z
26 Park, T.S. et al. Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells. Stem Cells 27, 783-795 (2009).
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脂肪细胞 adipocyte
* o$ ]8 j% |; h+ f: X; K27 Taura, D. et al. Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Letters 583, 1029-1033 (2009).
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4 T# p* ]2 [( `' o, D$ y1 i可能会有失误的地方,见谅!
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