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肝细胞 hepatocytes
4 I1 S; n. {' n E2 d% d1 Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010). 0 q1 V5 w, e' Q& o4 f; ~# Z% {; {
2 Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
0 S3 l* o- H/ y3 Sullivan, G.J. et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 51, 329-335 (2010).# q2 X* G/ |, M9 K. S, c
4 Si-Tayeb, K. et al. Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells. Hepatology 51, 297-305 (2010). @: y+ A9 E ^ q
5 Song, Z. et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res 19, 1233-1242 (2009)., \3 ?: x/ @$ ^, c4 r& h. `
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神经细胞
Y& E# p* M$ l: uneural crest precusors
4 p, {: R$ |6 Z6 Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).
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) }, ^& ]/ _, y( r" V, s3 Bneuroepithelial cell. G+ `. O- F$ ~* `4 o5 z8 z
7 Hu, B.-Y. et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of the National Academy of Sciences 107, 4335-4340 (2010) * n+ x3 U. @8 a l5 t! Z
& v. v/ d. B) Y7 p0 s2 zmotor neurons【包括文献7】0 V. U/ n7 G+ O% R. w% \/ P
8 Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
/ S+ O+ d& O# G/ {9 Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009). - `9 h. Q9 |# j6 c& m) G
10 Chambers, S.M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotech 27, 275-280 (2009). 0 B% q8 G& ~2 G2 _, ~3 x
) E# b5 X: i- n8 L5 S- ~8 qdopaminergic neurons of the midbrain 【包括文献10】. B* u$ ? {( |. w& j/ l0 _
11 Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
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glia 【包括文献7,8】
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% G2 b; ^1 }- `. |' A- s0 T2 a* L视网膜细胞
* v/ R# k; l, A4 \; k, lRetinal Pigmented Epithelium3 @( E+ P& ]( ^' h
12 Buchholz, D.E. et al. Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells. Stem Cells 27, 2427-2434 (2009).
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retinal cells7 H$ d i; b. F6 l
13 Osakada, F. et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci 122, 3169-3179 (2009).
& N# O" i6 p$ f1 N4 L14 Meyer, J.S. et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proceedings of the National Academy of Sciences 106, 16698-16703 (2009).
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心肌细胞 cardiomyocytes
5 J# S, A+ R, C3 \9 v/ Y15 Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
/ E6 L% D% X0 V. H+ i16 Carvajal-Vergara, X. et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465, 808-812 (2010).! I2 ?% g0 Q- k/ i( h- p+ i
17 Zhang, J. et al. Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells. Circ Res 104, e30-41 (2009).: l1 P# V5 K3 Y/ m
18 Zwi, L. et al. Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells. Circulation 120, 1513-1523 (2009).
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z) {) _) f, I6 r% ~) j血管和血液相关细胞
5 a( q6 R/ g. ^+ |1 W4 D7 |3 khaematopoietic progenitors( ^$ ?+ W* r2 r/ Z, \7 R0 P
19 Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
5 \8 y/ q( d& v5 c' i20 Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).2 V; K. v8 [+ z( ~0 S
" _( d5 Y; K* Qblood cells
1 l: o: }* y4 q3 j) f* H21 Choi, K.-D. et al. Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells 27, 559-567 (2009)./ [0 V1 N3 ? Q4 S
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vascular endothelial cells【包括文献21】9 X0 I4 C# {3 @
22 Feng, Q. et al. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence. Stem Cells 28, 704-712 (2010).! T, V. ]; i% M/ O0 S9 l5 m
23 Taura, D. et al. Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells--Brief Report. Arterioscler Thromb Vasc Biol 29, 1100-1103 (2009).
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, R8 D% _. x$ i胰岛素产生细胞 insulin-producing cells$ `0 Q0 y8 X5 k6 k# G
24 Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
9 M2 Q j, p+ H! ]25 Zhang, D. et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 19, 429-438 (2009).8 F8 l [" f/ p/ S1 F4 Q
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原生殖细胞 primordial germ cells' f/ Z( \$ [7 u; `1 R; Y
26 Park, T.S. et al. Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells. Stem Cells 27, 783-795 (2009).
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) k! \( W# ]/ L- A$ d脂肪细胞 adipocyte
1 g$ L2 M0 o: a. q! i27 Taura, D. et al. Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Letters 583, 1029-1033 (2009).
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* P: k7 B7 R3 X- `7 }1 R3 d& j2 F可能会有失误的地方,见谅!
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