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肝细胞 hepatocytes
+ A; g) t% ^1 X2 l# }0 `1 Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
/ G* q, f: ?; W4 F. ~% |2 Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
" m' R' S$ C- ]* a. b3 Sullivan, G.J. et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 51, 329-335 (2010).1 j, C# O* R& b- c
4 Si-Tayeb, K. et al. Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells. Hepatology 51, 297-305 (2010).
/ \5 I; L# [7 o. s) c) F5 Song, Z. et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res 19, 1233-1242 (2009).
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神经细胞
' x6 k5 ~! i. o# g: T" \; W) {neural crest precusors
3 a" j7 x) Y" a4 N; b6 m6 Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009). & T8 G( p# p6 o4 Z5 j
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neuroepithelial cell
5 z2 ~9 [# v5 a( u7 Hu, B.-Y. et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of the National Academy of Sciences 107, 4335-4340 (2010)
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3 ]) ` [% P+ N7 \4 u n+ lmotor neurons【包括文献7】
! p' j: W1 I# ^# N8 Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
0 g/ u. z4 [6 u: U* l8 Y) y9 Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
2 y* [+ }- Q1 C) t( h$ j* x10 Chambers, S.M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotech 27, 275-280 (2009).
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dopaminergic neurons of the midbrain 【包括文献10】
8 `7 o" n, k% ~* N9 k6 d11 Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
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6 w# M8 _* ^6 a$ G, P$ I7 n$ e# cglia 【包括文献7,8】# \) E' j: l& }+ C
' J5 K" T0 O% G6 ~视网膜细胞0 L8 ]; o* t R7 W: t
Retinal Pigmented Epithelium! Z0 O' l4 l% w ?; d* b# Y
12 Buchholz, D.E. et al. Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells. Stem Cells 27, 2427-2434 (2009).2 X8 I1 f! Q B( Y& c2 e
6 P6 i" I; {+ O s. @5 Bretinal cells6 y3 L' e( Y. p& t$ g# e; O
13 Osakada, F. et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci 122, 3169-3179 (2009).' q) R) j7 `+ O3 D/ d3 A5 J
14 Meyer, J.S. et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proceedings of the National Academy of Sciences 106, 16698-16703 (2009).
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心肌细胞 cardiomyocytes
! t) Q, i; a G( N15 Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
: O& w6 o# B7 N6 @& c16 Carvajal-Vergara, X. et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465, 808-812 (2010).
. V* ] t. V3 V! D8 o- g' e17 Zhang, J. et al. Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells. Circ Res 104, e30-41 (2009).
, w9 F; o& p! r* E18 Zwi, L. et al. Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells. Circulation 120, 1513-1523 (2009).
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血管和血液相关细胞2 i3 v7 M7 L0 u" B3 g2 d
haematopoietic progenitors0 a0 h* @/ @# J3 R, ?
19 Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
- o, n7 l# u6 h1 e( N% \# {+ _& Y5 b20 Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
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blood cells
9 u3 H6 _6 S% n, @21 Choi, K.-D. et al. Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells 27, 559-567 (2009).- z/ g" E" F0 [: x0 G5 T
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vascular endothelial cells【包括文献21】( y4 S* p4 Y/ y1 x+ m
22 Feng, Q. et al. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence. Stem Cells 28, 704-712 (2010).. r4 c' I* h0 r6 q2 S4 j$ r, A- X
23 Taura, D. et al. Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells--Brief Report. Arterioscler Thromb Vasc Biol 29, 1100-1103 (2009).6 `4 G/ D+ P; T- S
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胰岛素产生细胞 insulin-producing cells/ |2 o* j9 P( E/ I6 \
24 Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
9 j& I* n" h& a {9 a; ?5 u8 Q25 Zhang, D. et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 19, 429-438 (2009).- M. \/ g* x9 u; w
. g7 T! U u- u9 P& x9 r" a+ ~; p原生殖细胞 primordial germ cells* ]" X# O0 {% L
26 Park, T.S. et al. Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells. Stem Cells 27, 783-795 (2009).3 P# J% A+ L& |( S6 }3 B* a
/ C1 u; T2 M1 i* v J) b: _7 M' Z脂肪细胞 adipocyte" p5 W( [2 s% S. \- _' G: B* r
27 Taura, D. et al. Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Letters 583, 1029-1033 (2009)." {& i8 a4 l- @( q" I& F$ e( b
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