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肝细胞 hepatocytes
$ @5 A* O, l0 Y& p! w8 Y$ j4 A# f* B1 Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010). / \2 j* C( z0 H$ f' ?# o
2 Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
! `' n+ O6 p4 ?: ]3 u* }3 Sullivan, G.J. et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 51, 329-335 (2010).
, V: o$ i) \( [ @4 Si-Tayeb, K. et al. Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells. Hepatology 51, 297-305 (2010).
) M, [; x. s! H/ M6 c( R5 Song, Z. et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res 19, 1233-1242 (2009).
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神经细胞
# O4 O3 _+ t3 r! N9 Kneural crest precusors4 k5 }$ R$ u! ?
6 Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009). $ ?; d2 p: |2 S5 r+ B
2 x+ s. j8 x4 C8 J9 cneuroepithelial cell
7 }& S7 W" e% ?3 F$ s7 Hu, B.-Y. et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of the National Academy of Sciences 107, 4335-4340 (2010)
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0 H" u& r% \1 L5 S/ u1 Rmotor neurons【包括文献7】
) `2 m c$ d( t" U$ D! O5 T8 |0 Z8 Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).0 x t6 n/ N3 T {) S# J3 W: {) F
9 Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009). * `9 W: P' ~: |; B
10 Chambers, S.M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotech 27, 275-280 (2009).
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dopaminergic neurons of the midbrain 【包括文献10】. F* c4 F" T- z8 L2 k6 p( ~
11 Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009). 1 Y! [" T ^- {3 B% j8 ]
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glia 【包括文献7,8】7 _7 S3 {0 B- K7 k; S% a/ G4 x
% c" n& o0 j- l, b# t7 S视网膜细胞
# @ e6 I" S3 J* A& RRetinal Pigmented Epithelium
, }7 W. g5 K' s12 Buchholz, D.E. et al. Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells. Stem Cells 27, 2427-2434 (2009).2 [( y5 D0 }' E7 R/ ~! L
6 F+ T3 H; B* O& U& Jretinal cells5 j8 E7 ^ I) e& b; G& u$ s
13 Osakada, F. et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci 122, 3169-3179 (2009).3 z" O3 i1 I- Z `3 j& b
14 Meyer, J.S. et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proceedings of the National Academy of Sciences 106, 16698-16703 (2009).
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心肌细胞 cardiomyocytes
! _0 \# @# o; o* Q15 Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
( F( k, y+ {4 Q( l6 F; H& b( v16 Carvajal-Vergara, X. et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465, 808-812 (2010).! U/ t1 x; t( _& i E# E7 ^$ p8 ?
17 Zhang, J. et al. Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells. Circ Res 104, e30-41 (2009).
+ h" Y9 e, \. e" w( R18 Zwi, L. et al. Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells. Circulation 120, 1513-1523 (2009).$ K0 D+ Q0 F* P: Z2 q
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血管和血液相关细胞 m/ w1 t! R5 I# \: Q. v- e: [
haematopoietic progenitors
2 u1 E! [3 n4 W1 ` i19 Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009)./ B2 ?3 X P: c: I! }' h }# @4 l" G
20 Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009)." x" f1 ~3 @* P6 A" {" X: F/ y
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blood cells; e; K: t ^( C" m3 {
21 Choi, K.-D. et al. Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells 27, 559-567 (2009).
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, X k1 w9 y# t F d3 V: D8 Pvascular endothelial cells【包括文献21】
" _7 K1 `( _) h, p22 Feng, Q. et al. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence. Stem Cells 28, 704-712 (2010).8 l, `5 T# z! r3 N3 Z8 B
23 Taura, D. et al. Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells--Brief Report. Arterioscler Thromb Vasc Biol 29, 1100-1103 (2009).
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0 S% j; u) N2 q/ O6 o& r胰岛素产生细胞 insulin-producing cells. W0 r5 b1 n {# F
24 Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
4 h) [5 R- j4 _) E1 A8 c25 Zhang, D. et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 19, 429-438 (2009).8 U! ^6 Z/ R% n/ @, Y& F5 V
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原生殖细胞 primordial germ cells( R' Q, z3 G3 I" y. x7 e" V
26 Park, T.S. et al. Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells. Stem Cells 27, 783-795 (2009).
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脂肪细胞 adipocyte
+ U6 N) \* p2 v0 n$ F/ ~, v27 Taura, D. et al. Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Letters 583, 1029-1033 (2009).0 ]0 u/ f' Q& o7 P) m
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5 r8 k% S* ^0 ?( K5 L, c9 Q+ d可能会有失误的地方,见谅!; k( Y/ y0 X- ^ H
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