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肝细胞 hepatocytes0 U; P" C8 e9 t# h3 a, `% N- m
1 Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
7 x1 h& c) M: V6 Q: L- L4 ]2 Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010). 4 V1 r: s2 ^/ N6 p. z5 i
3 Sullivan, G.J. et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 51, 329-335 (2010).: G8 ?4 A6 z: X; E3 z
4 Si-Tayeb, K. et al. Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells. Hepatology 51, 297-305 (2010).
d+ ]' ]/ f# p: Z5 Song, Z. et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res 19, 1233-1242 (2009).( W* m8 p! V% o F8 V. [' R
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神经细胞
7 y' `7 S- ~% B/ @, a) P' Dneural crest precusors6 A8 |" m( R/ @7 O- o, S5 T3 r
6 Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009). . \3 x# E x2 x* q* h7 h0 C
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neuroepithelial cell
* {7 X6 h+ {+ ?- ?5 s& K7 Hu, B.-Y. et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of the National Academy of Sciences 107, 4335-4340 (2010)
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motor neurons【包括文献7】
: D" \* j) h" u/ `9 A7 X* N% B8 Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).7 p y+ ~& L a' n' N# E
9 Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009). 0 K& H! e. F/ p$ d$ ^
10 Chambers, S.M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotech 27, 275-280 (2009). 1 @% P4 T0 c# ]& e) R9 o8 k
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dopaminergic neurons of the midbrain 【包括文献10】2 T4 p6 Z6 ]* R
11 Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009). ! J1 C1 z1 s& g# [& W) [, I
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glia 【包括文献7,8】, n8 W \) u9 s+ |- {5 {
6 A7 [+ N) t2 U# L, V视网膜细胞& O2 L& x6 A. P5 D. c c; c, y. H, f! v
Retinal Pigmented Epithelium5 A3 v5 P4 v0 A; _9 c
12 Buchholz, D.E. et al. Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells. Stem Cells 27, 2427-2434 (2009).
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0 f, r2 ~( O& _1 {7 K$ ^/ xretinal cells
- ]5 z, T, B! {7 Z$ G13 Osakada, F. et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci 122, 3169-3179 (2009).
1 `& {; n8 i. H% ~5 U) h14 Meyer, J.S. et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proceedings of the National Academy of Sciences 106, 16698-16703 (2009).
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心肌细胞 cardiomyocytes
, @! f9 J. @; i15 Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
' s3 ]* R- ?; H; }( w R6 I0 _16 Carvajal-Vergara, X. et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465, 808-812 (2010).
" o& F( }1 m, t* q17 Zhang, J. et al. Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells. Circ Res 104, e30-41 (2009).
4 F4 l* E6 F! K0 r18 Zwi, L. et al. Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells. Circulation 120, 1513-1523 (2009).
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, |# z' j# o$ `% w% A( m血管和血液相关细胞
7 o5 k- Z0 F: v" t& R6 Yhaematopoietic progenitors9 H9 n+ E: @) E: |6 D
19 Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).7 |+ B+ @# q v6 \+ [& d2 ?" w0 T, ~
20 Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).% [5 G/ y' T# O& D* ~
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blood cells/ {9 z w( a" Y( [8 q
21 Choi, K.-D. et al. Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells 27, 559-567 (2009).
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vascular endothelial cells【包括文献21】8 j6 o" |$ j% l6 ]2 ~! t& A8 d
22 Feng, Q. et al. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence. Stem Cells 28, 704-712 (2010).$ O% W+ b% K, e( ]
23 Taura, D. et al. Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells--Brief Report. Arterioscler Thromb Vasc Biol 29, 1100-1103 (2009)., r) |. }5 s6 [
$ |8 a9 p2 z1 R' Q胰岛素产生细胞 insulin-producing cells0 i3 @/ |1 t/ ` d1 n2 d1 l
24 Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
& A4 ~* N9 s* f25 Zhang, D. et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 19, 429-438 (2009).. Z# t5 M f/ E6 \+ w3 I
- b. s/ y8 S' H; E- G t原生殖细胞 primordial germ cells2 `1 V1 h1 B$ G! F& C
26 Park, T.S. et al. Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells. Stem Cells 27, 783-795 (2009).
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% \, \# F$ Y3 P$ r% K9 v脂肪细胞 adipocyte: K& C3 x# t: D1 J* _
27 Taura, D. et al. Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Letters 583, 1029-1033 (2009).
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