两篇关于表观遗传与神经系统的不错的文章

regene

Epigenetic choreographers of neurogenesis
* T! I: m( D! U, @4 Q& s' Kin the adult mammalian brain
: Q. d) Y. V: r/ C: j/ aVOLUME 13 | NUMBER 11 | NOVEMBER 2010    nature neuroscience- S, u0 s5 {4 c+ I/ c
Dengke K Ma1, Maria Carolina Marchetto2, Junjie U Guo3,4, Guo-li Ming3–5, Fred H Gage2 & Hongjun Song3–5
% c. Z( _& P- H. V$ dEpigenetic mechanisms regulate cell differentiation during embryonic development and also serve as important interfaces % T& `9 {8 T. J
between genes and the environment in adulthood. Neurogenesis in adults, which generates functional neural cell types from " i8 G- z. j  a, b3 r6 {: C4 v
adult neural stem cells, is dynamically regulated by both intrinsic state-specific cell differentiation cues and extrinsic neural
# k$ l; y! t0 I% e; i7 \niche signals. Epigenetic regulation by DNA and histone modifiers, non-coding RNAs and other self-sustained mechanisms can
; M- E. c8 k, q- y- Q' rlead to relatively long-lasting biological effects and maintain functional neurogenesis throughout life in discrete regions of the ' O4 |! p; @& D$ i5 F
mammalian brain. Here, we review recent evidence that epigenetic mechanisms carry out diverse roles in regulating specific / u1 a  O0 u: D, c- p" W
aspects of adult neurogenesis and highlight the implications of such epigenetic regulation for neural plasticity and disorders.
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Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways Antonella Riccio
8 h; }" h5 z  _+ X; G  F7 NVOLUME 13 | NUMBER 11 | NOVEMBER 2010   nature neurOSCIenCe, ]0 H, s4 C6 l1 c- p
The development and function of neurons require the regulated expression of large numbers of very specific gene sets. Epigenetic
. U9 j, e, _! Umodifications of both DNA and histone proteins are now emerging as fundamental mechanisms by which neurons adapt their " c7 h3 i- l* f8 R
transcriptional response to developmental and environmental cues. In the nervous system, the mechanisms by which extracellular 4 |( m; m- j# V
signals regulate the activity of chromatin-modifying enzymes have just begun to be characterized. In this Review, I discuss
& f- q2 d2 X& w, h/ Dhow extracellular cues, including synaptic activity and neurotrophic factors, influence epigenetic modifications and regulate   Z& x) _4 J+ z
the neuronal transcriptional response. I also summarize additional mechanisms that induce chromatin remodeling events by & V/ ^( S# H* ]. e% ~  T9 [
combinatorial assembly of multiprotein complexes on neuronal gene promoters.