两篇关于表观遗传与神经系统的不错的文章

regene

Epigenetic choreographers of neurogenesis
3 `& ~) j8 l3 V( pin the adult mammalian brain
1 z- ~( Y$ x; l. CVOLUME 13 | NUMBER 11 | NOVEMBER 2010    nature neuroscience
3 L' g' l2 `  pDengke K Ma1, Maria Carolina Marchetto2, Junjie U Guo3,4, Guo-li Ming3–5, Fred H Gage2 & Hongjun Song3–5
4 ^( N) V6 e9 A" m3 G- r& vEpigenetic mechanisms regulate cell differentiation during embryonic development and also serve as important interfaces
+ i) a  ~0 t0 o- M; \" M# R, ubetween genes and the environment in adulthood. Neurogenesis in adults, which generates functional neural cell types from
- B, v+ E* ~7 X) @" @5 D! j, Kadult neural stem cells, is dynamically regulated by both intrinsic state-specific cell differentiation cues and extrinsic neural
9 e! u5 Y* e" A/ g& S5 P9 Sniche signals. Epigenetic regulation by DNA and histone modifiers, non-coding RNAs and other self-sustained mechanisms can
& _( M3 H/ T7 ?7 [2 olead to relatively long-lasting biological effects and maintain functional neurogenesis throughout life in discrete regions of the
5 h  g. d+ X. Y' cmammalian brain. Here, we review recent evidence that epigenetic mechanisms carry out diverse roles in regulating specific : ]/ E4 N8 e7 e9 t+ j6 V2 W7 s* x
aspects of adult neurogenesis and highlight the implications of such epigenetic regulation for neural plasticity and disorders.
  t. U9 D/ u; c6 y9 i- y& ?
! _: q2 V3 j1 z1 o! [9 B7 v8 v' I
Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways Antonella Riccio+ |0 {  _: u) Y
VOLUME 13 | NUMBER 11 | NOVEMBER 2010   nature neurOSCIenCe
! k4 f9 M5 ]" w! h, d) bThe development and function of neurons require the regulated expression of large numbers of very specific gene sets. Epigenetic 3 f: ^: e& n- }, R/ a
modifications of both DNA and histone proteins are now emerging as fundamental mechanisms by which neurons adapt their 0 O4 C+ a/ x9 i, Y  {5 O
transcriptional response to developmental and environmental cues. In the nervous system, the mechanisms by which extracellular , x$ b3 O% n+ L% H+ t
signals regulate the activity of chromatin-modifying enzymes have just begun to be characterized. In this Review, I discuss
  H0 X# N- a. {- w# Show extracellular cues, including synaptic activity and neurotrophic factors, influence epigenetic modifications and regulate " B- S% ]6 r* B7 I  Z
the neuronal transcriptional response. I also summarize additional mechanisms that induce chromatin remodeling events by
9 ^" g% }( s) w# ^combinatorial assembly of multiprotein complexes on neuronal gene promoters.