两篇关于表观遗传与神经系统的不错的文章

regene

Epigenetic choreographers of neurogenesis 4 M  C+ @- E- U
in the adult mammalian brain' ~# N. m1 I) ~! g4 r# [
VOLUME 13 | NUMBER 11 | NOVEMBER 2010    nature neuroscience
8 k. ^* Q8 l0 ^4 w3 wDengke K Ma1, Maria Carolina Marchetto2, Junjie U Guo3,4, Guo-li Ming3–5, Fred H Gage2 & Hongjun Song3–5
" a# E8 F3 |6 E! e$ L, O2 eEpigenetic mechanisms regulate cell differentiation during embryonic development and also serve as important interfaces % W+ d/ I. T& a
between genes and the environment in adulthood. Neurogenesis in adults, which generates functional neural cell types from # v7 F8 T, X$ A( V1 v- Y: B
adult neural stem cells, is dynamically regulated by both intrinsic state-specific cell differentiation cues and extrinsic neural
; Z8 A" b9 ]( Q5 X' jniche signals. Epigenetic regulation by DNA and histone modifiers, non-coding RNAs and other self-sustained mechanisms can
, A1 x* `( v3 `" Rlead to relatively long-lasting biological effects and maintain functional neurogenesis throughout life in discrete regions of the   Q7 {, C9 J: \$ t8 u
mammalian brain. Here, we review recent evidence that epigenetic mechanisms carry out diverse roles in regulating specific $ o( F- `( q# O: H  R# W
aspects of adult neurogenesis and highlight the implications of such epigenetic regulation for neural plasticity and disorders.
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Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways Antonella Riccio
8 `. {; T/ H; [, n/ }# v  g/ qVOLUME 13 | NUMBER 11 | NOVEMBER 2010   nature neurOSCIenCe% r/ C/ u5 g$ k0 D
The development and function of neurons require the regulated expression of large numbers of very specific gene sets. Epigenetic ( y9 o, Z4 J, }5 a
modifications of both DNA and histone proteins are now emerging as fundamental mechanisms by which neurons adapt their
6 q- e2 j" Q' j3 E8 Ltranscriptional response to developmental and environmental cues. In the nervous system, the mechanisms by which extracellular
7 h, [* g3 B' zsignals regulate the activity of chromatin-modifying enzymes have just begun to be characterized. In this Review, I discuss 0 B  A0 i$ a$ I9 G% f, X
how extracellular cues, including synaptic activity and neurotrophic factors, influence epigenetic modifications and regulate
; v/ g" G9 M4 j+ I; K* `9 u. mthe neuronal transcriptional response. I also summarize additional mechanisms that induce chromatin remodeling events by + E# o& N: T4 I! _
combinatorial assembly of multiprotein complexes on neuronal gene promoters.