2008年Cell杂志的一期不错的干细胞特刊

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/ ^4 X3 Z: q5 K! @8 U最近浏览期刊，发现2008年Cell杂志有一期干细胞研究的综述，内容非常全面，感觉对大家非常有用，可以作为教材来研究学习。下载时把文章的补充材料也下下来，供大家学习。8 u' S' O4 ]/ m4 R# i
Stem cells have two remarkable abilities: they can self-renew to keep the stem cell pool replenished, and
& h1 x6 u5 e( V9 p. V7 Xthey can differentiate into a wide variety of cell types. This stunning biological duality intrigues not only
& }3 H) M; U# G3 S* N' ethose interested in the basic mechanisms of development, differentiation, and reprogramming, but
! W& p9 q( o! k! T5 z) kalso those who seek to use stem cells therapeutically to replace lost or damaged tissue. But when did: C# e9 j7 D, X6 I4 P: ~
the stem cell revolution start? It was back in the 1960s that two Canadian researchers, Ernest A. McCulloch7 f; T$ p! q& b' z
and James E. Till, launched the field of stem cell research with their groundbreaking work on the hematopoietic
9 r' Y6 W+ `% X/ O- A' cstem cells of mouse bone marrow. By designing clonogenic assays to measure stem cell differentiation
6 g( R" \* Z. G+ w$ e. q7 u. Hin vitro and serial transplantation assays to study stem cell repopulating ability in vivo, Till and
1 J5 o2 K& x; b$ lMcCulloch defined the hallmark characteristics of stem cells.
' f6 w* n& w7 @% I9 q8 BThe field of stem cell research has come a long way in 50 years, as we hope will be apparent from this
- p) H& N% f8 r" f+ H* a$ G4 Wyear’s Special Review Issue. Our goal in this issue is to highlight the remarkable biological features of
' u' `6 J7 n( A+ Vstem cells, the molecular pathways that control these characteristics, and the ways in which these enigmatic" K, h9 M4 e* Y# P8 K
cells can be exploited for cell replacement therapy. We would like to thank the many distinguished3 q8 G1 q- V% g( X3 P- o3 d
experts who contributed their time and efforts as authors and reviewers to make this special issue on
8 t' f2 J: f* M- D+ h0 ?3 p# q0 Vstem cells informative, thought-provoking, and timely. We hope that this collection of articles conveys
0 D7 a) y! W- ^- x4 }0 Uthe excitement and promise of stem cell research, as we enter a new era of possibility.

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