求助Annu Rev Biochem. 2007;76:447-80.文献

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Annu Rev Biochem. 2007;76:447-80.
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Signaling pathways downstream of pattern-recognition receptors and their cross talk.
, y0 K* i# h% K3 l0 t4 WLee MS, Kim YJ.  v6 g% l' O0 E0 v$ k3 V

1 n! m3 s2 D2 ^% G1 oDepartment of Biochemistry, Yonsei University, Seoul 120-749, Republic of Korea. myeongsup.lee@gmail.com, X. V) z( _$ ?; Q! s/ ^# ~& W

5 N6 e, h( x, k# GAbstract
+ L. }" l, z: jPattern-recognition receptors (PRRs) initiate innate immunity through pathogen recognition. Serum PRRs opsonize pathogens for enhanced phagocytic clearance. Toll-like receptors (TLRs) initiate common NF-kappaB/AP-1 and distinct IRF3/7 pathways to coordinate innate immunity and to initiate adaptive immunity against diverse pathogens. Cytoplasmic caspase-recruiting domain (CARD) helicases, such as RIG-I/MDA5, mediate antiviral immunity by inducing the production of type I interferons via the adaptor IPS-1, whereas nucleotide-binding oligomerization domain (NOD)-like receptors mediate mainly antibacterial immunity by activating NF-kappaB or inflammasomes. Dectin-1 is important for antifungal immunity, promoting phagocytosis and activating NF-kappaB. Potentially harmful TLR signaling pathways can be negatively regulated by negative feedback mechanisms and also by anti-inflammatory factors such as TGFbeta, interleukin (IL)-10, and steroids. Many combinations of TLR-TLR and TLR-NOD modulate inflammatory responses. TLRs and NALP3 interplay to produce mature IL-1beta. Thus signaling pathways downstream of PRRs and their cross talk control immune responses in effective manners.3 F# Y, O5 E3 }; v% M- F
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