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本帖最后由 l19rna 于 2011-4-6 22:31 编辑
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. a0 z# [' i' l6 U% p, I9 z" k建议你看文献the hallmarks of cancer: the next generation, 里面有详述参与肿瘤形成的各种细胞。附一张截图
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附原文
4 `; T0 ?, v, j& m(Upper) An assemblage of distinct cell types constitutes; O6 e4 b& Q4 Z7 F! d
most solid tumors. Both the parenchyma and stroma of& x4 v0 }4 _1 q7 G, U
tumors contain distinct cell types and subtypes that
, i1 B7 S% o% o4 qcollectively enable tumor growth and progression.
4 k$ X/ w# Y; m! s& q; \# M, e3 V" PNotably, the immune inflammatory cells present in tumors
% R' t$ R9 |. o9 f' o8 gcan include both tumor-promoting as well as tumor-killing
E* v) b3 W% P2 d: F# Hsubclasses.. Y: O# _4 z2 r% ^1 r" l
(Lower) The distinctive microenvironments of tumors. The
x* v7 h1 I' Z2 b) F6 R& Rmultiple stromal cell types create a succession of tumor
) }5 ]1 A' v% T( _- p# cmicroenvironments that change as tumors invade normal2 A# g0 n3 r, w& ]/ P5 _
tissue and thereafter seed and colonize distant tissues.$ k5 y, ^) r: D' U
The abundance, histologic organization, and phenotypic
, ?. z3 n3 w. g. j& U8 T/ _characteristics of the stromal cell types, as well as of the
9 P' N9 b. k* G* s, @8 ]# textracellular matrix (hatched background), evolve during
3 l7 w% H! o# cprogression, thereby enabling primary, invasive, and then
: o+ y* b' m9 R. }" T# Smetastatic growth. The surrounding normal cells of the
. i9 J; O; u+ F5 N, b) oprimary and metastatic sites, shown only schematically,# e: d' h& R$ X6 q
likely also affect the character of the various neoplastic# N4 ?- a/ v5 |4 o
microenvironments. (Not shown are the premalignant5 O( I, B* z) R: V1 d q5 G
stages in tumorigenesis, which also have distinctive8 }! i. O! J$ h; O Q* U* A: O
microenvironments that are created by the abundance7 Z' h! F0 u1 v0 b! _7 C
and characteristics of the assembled cells.) |
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发表于 2011-4-6 21:17
发表于 2011-4-6 23:15
