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本帖最后由 l19rna 于 2011-4-6 22:31 编辑
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; x/ w7 |1 G5 t# W! u9 k" S$ b建议你看文献the hallmarks of cancer: the next generation, 里面有详述参与肿瘤形成的各种细胞。附一张截图
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$ C9 V. I8 z7 d* s2 I附原文3 I- q# S1 ~- e* z4 T
(Upper) An assemblage of distinct cell types constitutes
% B7 ^8 D) e$ ?, m5 `* G8 |6 A Kmost solid tumors. Both the parenchyma and stroma of
- z% P( H) \5 J7 F) @) Ytumors contain distinct cell types and subtypes that4 S; t6 R& f: Y# Y
collectively enable tumor growth and progression.& x: Y( G( C$ Q# O
Notably, the immune inflammatory cells present in tumors+ K/ g8 g$ ^7 {7 N5 u- m
can include both tumor-promoting as well as tumor-killing
: z4 H3 M' {4 ksubclasses.
, G9 A% a D [(Lower) The distinctive microenvironments of tumors. The
' f+ C5 q$ w5 \& S, i" K) y" Wmultiple stromal cell types create a succession of tumor
4 B+ a3 T& J' D S% _5 ~microenvironments that change as tumors invade normal
% Z" B) m* q3 Otissue and thereafter seed and colonize distant tissues.
8 D ?, N: x. \' i% d7 F6 }The abundance, histologic organization, and phenotypic
7 X: T, W. ?! b. c! ~# _9 ?5 vcharacteristics of the stromal cell types, as well as of the
+ i! }- B8 `* r7 s* N" Z' {extracellular matrix (hatched background), evolve during' J) u6 Q' M& C* V( Z
progression, thereby enabling primary, invasive, and then
( |& X& U" V2 w/ R0 z* D Emetastatic growth. The surrounding normal cells of the& U+ M4 w/ s' k+ y7 q4 Z
primary and metastatic sites, shown only schematically, R5 N0 {0 W8 L* `* o
likely also affect the character of the various neoplastic
# A/ y% ^5 \% v1 ?/ ~, G) Vmicroenvironments. (Not shown are the premalignant- y E. T6 _. d4 N5 Y1 r
stages in tumorigenesis, which also have distinctive- v+ D5 P; _% }
microenvironments that are created by the abundance
* ^/ u3 s( ~( ?" vand characteristics of the assembled cells.) |
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发表于 2011-4-6 21:17
发表于 2011-4-6 23:15
