肿瘤干细胞与正常干细胞之间的交流

qwmwolf

肿瘤已经成为现在研究的热点，而肿瘤组织中存在着肿瘤干细胞的假说也越来越为更多的人所接受，肿瘤干细胞，在一定的环境下异常增殖分化形成肿瘤，那么这样一个环境应该是会对正常干细胞有一定的作用，至于有些什么作用，是募集正常干细胞进入肿瘤干细胞的微环境参与肿瘤的发生发展还是有其他的作用，希望大家能参与讨论。

光风霁月

有文献报道，正常干细胞也可在特定的环境（促进肿瘤发生的环境）下，促进肿瘤的发生

l19rna

3 m2 L; H! T9 ]0 Z5 e8 G+ F4 ^) t) v
建议你看文献the hallmarks of cancer: the next generation, 里面有详述参与肿瘤形成的各种细胞。附一张截图
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附原文& u; }! h" _" |( {/ T
(Upper) An assemblage of distinct cell types constitutes/ ?3 Y, ]" q( E; F9 X
most solid tumors. Both the parenchyma and stroma of$ f6 j; k' @4 I/ \! P- k- R
tumors contain distinct cell types and subtypes that
2 ?' |, v1 d: w) |- Y% ncollectively enable tumor growth and progression.+ H( Q; `# n+ h
Notably, the immune inflammatory cells present in tumors
1 p" _4 N# Y2 M6 O7 C# @can include both tumor-promoting as well as tumor-killing
3 @4 l( k. v) k& S( I5 Bsubclasses.
! s4 `9 h, t* g(Lower) The distinctive microenvironments of tumors. The8 u) S/ b2 n7 S8 @
multiple stromal cell types create a succession of tumor/ o1 l9 {  w" U. t. p6 l+ R: B' D, [7 L3 M
microenvironments that change as tumors invade normal2 W7 f- v) x' a# }$ f# f2 ~0 g
tissue and thereafter seed and colonize distant tissues.
7 O+ H* A1 o6 e2 S  |: ?# }The abundance, histologic organization, and phenotypic
- a0 W2 u$ q, y$ T4 Vcharacteristics of the stromal cell types, as well as of the5 p' r$ K' Y* E3 D+ f0 Z
extracellular matrix (hatched background), evolve during
- B7 H0 ]; |  b. M( E& dprogression, thereby enabling primary, invasive, and then
7 m1 [: \$ \( @# t+ p. u$ Mmetastatic growth. The surrounding normal cells of the
! c9 E$ L& `1 ^1 ^1 `# jprimary and metastatic sites, shown only schematically,1 x4 `, \" f( j7 i* e* q- R2 g; c
likely also affect the character of the various neoplastic
% Q, [! S) O+ ]9 \) ^microenvironments. (Not shown are the premalignant' [5 @* M: L  X% G
stages in tumorigenesis, which also have distinctive+ H1 r1 q) l7 [; \
microenvironments that are created by the abundance( o7 B" R/ g0 E
and characteristics of the assembled cells.)

embryonic12

肿瘤组织可招募成体干细胞到其壁龛中，但作用不知

懵懂干细胞

这一点在多篇文献中都有报道，就连机体的免疫系统从某些程度也起到促进其逃逸！

鹤顶宏

机体内某些细胞因子影响淋巴细胞对肿瘤细胞免疫作用，进而促进肿瘤细胞转移等

hkenb

可能肿瘤干细胞这一概念是欠妥的，由于肿瘤往往具有异质性！